Hepatitis B Virus DNA and RNA Persist in Liver After Serologic Recovery in Persons With Hepatitis C Virus-Reference-Cited by-同舟云学术

Hepatitis B Virus DNA and RNA Persist in Liver After Serologic Recovery in Persons With Hepatitis C Virus

Published:2024-05-23 Issue: Volume: Page:
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Grudda Tanner¹^ORCID,Thomas David L²³,Kirk Gregory D²³,Mehta Shruti H²,Astemborski Jacquie²,Lauer Georg M⁴⁵,Balagopal Ashwin²^ORCID,Thio Chloe L¹²^ORCID

Affiliation:

1. Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health , Baltimore, Maryland , USA

2. Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland , USA

3. Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health , Baltimore, Maryland , USA

4. Division of Gastroenterology, Massachusetts General Hospital , Boston, Massachusetts , USA

5. Department of Medicine, Harvard Medical School , Boston, Massachusetts , USA

Abstract

Abstract After recovery from a hepatitis B virus (HBV) infection, reactivation can occur with immunosuppression; thus, it is assumed that replication competent HBV persists in the liver. We sought to detect persistent HBV from 13 people with spontaneous recovery. We quantified HBV DNA and RNA in core liver biopsy specimens (median, 1.72 × 106 cells) from persons who inject drugs. Of 13 biopsy specimens, 8 (61%) had evidence of HBV DNA or RNA and 5 (38%) had both HBV DNA and RNA. Messenger RNAs were derived from covalently closed circular DNA and integrated HBV DNA. Here, we show prevalent HBV DNA and RNA despite clinical recovery in persons who inject drugs.

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiae248/58179494/jiae248.pdf

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