Genetic Diversity From Proviral DNA as a Proxy for Time Since HIV-1 Infection-Reference-Cited by-同舟云学术

Genetic Diversity From Proviral DNA as a Proxy for Time Since HIV-1 Infection

Published:2024-03-20 Issue: Volume: Page:
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Zeeb Marius¹²^ORCID,Frischknecht Paul¹,Huber Michael²^ORCID,Schenkel Corinne D¹,Neumann Kathrin¹,Leeman Christine¹,Notter Julia³,Rauch Andri⁴^ORCID,Stöckle Marcel⁵⁶^ORCID,Cavassini Matthias⁷^ORCID,Bernasconi Enos⁸^ORCID,Braun Dominique L¹,Günthard Huldrych F¹²,Metzner Karin J¹²,Kouyos Roger D¹²

Affiliation:

1. Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich , Zurich , Switzerland

2. Institute of Medical Virology, University Zurich , Zurich , Switzerland

3. Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St Gallen , St Gallen , Switzerland

4. Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern , Bern , Switzerland

5. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel , Basel , Switzerland

6. Medical Faculty, University of Basel , Basel , Switzerland

7. Division of Infectious Diseases, University Hospital Lausanne, University of Lausanne , Lausanne , Switzerland

8. Division of Infectious Diseases, Ente Ospedaliero Cantonale, University of Geneva and University of Southern Switzerland , Lugano , Switzerland

Abstract

Abstract HIV-1 RNA genetic diversity predicts time since infection, which is important for clinical care and research. It is unclear, however, whether proviral DNA genetic diversity sampled under suppressive antiretroviral therapy can be used for this purpose. We tested whether proviral genetic diversity from next-generation sequencing predicts time since infection and recency in 221 people with HIV-1 with known infection time. Proviral diversity was significantly associated with time since infection (P < 5×10−7, R2 up to 25%) and predictive of treatment initiation during recent infection (area under the curve-receiver operating characteristic up to 0.85). This shows the utility of proviral genetic diversity as a proxy for time since infection.

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiae149/57337991/jiae149.pdf

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