A Bivalent Human Norovirus Vaccine Induces Homotypic and Heterotypic Neutralizing Antibodies

Author:

Atmar Robert L12ORCID,Ettayebi Khalil2ORCID,Ramani Sasirekha2ORCID,Neill Frederick H2,Lindesmith Lisa3ORCID,Baric Ralph S3ORCID,Brinkman Amanda4,Braun Ralph4,Sherwood James5,Estes Mary K12ORCID

Affiliation:

1. Department of Medicine

2. Department of Molecular Virology and Microbiology, Baylor College of Medicine , Houston, Texas

3. Department of Epidemiology, University of North Carolina , Chapel Hill

4. Takeda Vaccines Inc , Cambridge, Massachusetts

5. Takeda Pharmaceuticals International AG , Zurich , Switzerland

Abstract

Abstract A GII.2 outbreak in an efficacy study of a bivalent virus-like particle norovirus vaccine, TAK-214, in healthy US adults provided an opportunity to examine GII.4 homotypic vs GII.2 heterotypic responses to vaccination and infection. Three serologic assays—virus-like particle binding, histoblood group antigen blocking, and neutralizing—were performed for each genotype. Results were highly correlated within a genotype but not between genotypes. Although the vaccine provided protection from GII.2-associated disease, little GII.2-specific neutralization occurred after vaccination. Choice of antibody assay can affect assessments of human norovirus vaccine immunogenicity.

Funder

Takeda Vaccines, Inc

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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