Hospitalization and Mortality Risk for COVID-19 Cases With SARS-CoV-2 AY.4.2 (VUI-21OCT-01) Compared to Non-AY.4.2 Delta Variant Sublineages-Reference-Cited by-同舟云学术

Hospitalization and Mortality Risk for COVID-19 Cases With SARS-CoV-2 AY.4.2 (VUI-21OCT-01) Compared to Non-AY.4.2 Delta Variant Sublineages

Published:2022-02-20 Issue:5 Volume:226 Page:808-811
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Nyberg Tommy¹^ORCID,Harman Katie²^ORCID,Zaidi Asad²^ORCID,Seaman Shaun R¹^ORCID,Andrews Nick³^ORCID,Nash Sophie G²^ORCID,Charlett Andre⁴^ORCID,Lopez Bernal Jamie³^ORCID,Myers Richard⁵^ORCID,Groves Natalie⁵^ORCID,Gallagher Eileen⁵,Gharbia Saheer⁶^ORCID,Chand Meera⁵^ORCID,Thelwall Simon²^ORCID,De Angelis Daniela¹^ORCID,Dabrera Gavin²^ORCID,Presanis Anne M¹^ORCID

Affiliation:

1. Medical Research Council Biostatistics Unit, University of Cambridge , Cambridge , United Kingdom

2. COVID-19 National Epidemiology Cell, UK Health Security Agency , London , United Kingdom

3. Immunisation and Countermeasures Division, UK Health Security Agency , London , United Kingdom

4. National Infection Service, UK Health Security Agency , London , United Kingdom

5. Genomics Cell, UK Health Security Agency , London , United Kingdom

6. Genomics Programme, UK Health Security Agency , London , United Kingdom

Abstract

Abstract To investigate if the AY.4.2 sublineage of the SARS-CoV-2 delta variant is associated with hospitalization and mortality risks that differ from non-AY.4.2 delta risks, we performed a retrospective cohort study of sequencing-confirmed COVID-19 cases in England based on linkage of routine health care datasets. Using stratified Cox regression, we estimated adjusted hazard ratios (aHR) of hospital admission (aHR = 0.85; 95% confidence interval [CI], .77–.94), hospital admission or emergency care attendance (aHR = 0.87; 95% CI, .81–.94), and COVID-19 mortality (aHR = 0.85; 95% CI, .71–1.03). The results indicate that the risks of hospitalization and mortality are similar or lower for AY.4.2 compared to cases with other delta sublineages.

Funder

United Kingdom Research and Innovation Medical Research Council

Department of Health and Social Care National Institute for Health Research

NIHR Health Protection Unit in Behavioural Science and Evaluation

NIHR Cambridge Biomedical Research Centre

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiac063/42843082/jiac063.pdf

Reference15 articles.