Epidemiological and Clinical Characteristics of 26 Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Carriers

Author:

Pan Yanfeng1,Yu Xue1,Du Xinwei2,Li Qingqing1,Li Xianyang3,Qin Tao4,Wang Miaomiao5,Jiang Minlin6,Li Jie7,Li Weiguo8,Zhang Qian9,Xu Zhiwei10,Zhang Lu11

Affiliation:

1. Department of Infectious Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China

2. Department of Infectious Diseases, The People’s Hospital of Suzhou New District, Suzhou, Jiangsu, China

3. Department of Infectious Diseases, Shenqiu County People’s Hospital, Zhoukou City, Henan Province, China

4. Department of Hepatobiliary Surgery, Henan Provincial People’s Hospital, Zhengzhou, Henan Province, China

5. Department of Disease Control and Prevention, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China

6. Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Shanghai, China

7. Department of Infectious Diseases, Xiayi County People’s Hospital, Shangqiu City, Henan Province, China

8. Department of Infectious Diseases, Zhumadian Central Hospital, Zhumadian, Henan Province, China

9. Department of Infectious Diseases, Henan Provincial People’s Hospital, Zhengzhou, Henan Province, China

10. Clinical Research Service Center, Henan Provincial People’s Hospital, Zhengzhou, Henan Province, China

11. Department of Infectious Diseases, Yongcheng People’s Hospital, Shangqiu City, Henan Province, China

Abstract

Abstract Background We retrospectively analyzed 26 persistently asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carriers. Methods Epidemiological and clinical characteristics from the 26 asymptomatic patients with positive results for SARS-CoV-2 ribonucleic acid testing were obtained. Results Twenty-two patients (84.6%) correlated with clustering occurrence. The median period from contact to diagnosis and the last positive nucleic acid test was 19 (8–24 days) and 21.5 days (10–36 days), respectively. The median period from diagnosis to negative nucleic acid test was significantly different between patients with normal or atypical chest computed tomography (CT) findings (n = 16, 61.5%; 7.5 days [2–20 days]) and patients with typical ground-glass or patchy opacities on CT (n = 10, 38.5%; 12.5 days [8–22 days]; P < .01). Seven patients (70.0%) with initial positive nucleic acid test results had a negative result simultaneously with improved CT findings. Obvious improvement in CT findings was observed in 3 patients (30.0%) despite positive nucleic acid test results. Conclusions In asymptomatic patients, changes in biochemical and inflammatory variables are small and changes on chest CT can occur. It is worth noting that the long existence of SARS-CoV-2 in some asymptomatic patients and false-negative results need to be considered in SARS-CoV-2 nucleic acid test.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Reference18 articles.

1. The Wuhan SARS-CoV-2—What’s next for China;Lu;J Med Virol,2020

2. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia;Li;N Engl J Med,2020

3. Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany;Rothe;N Engl J Med,2020

4. Estimation of the asymptomatic ratio of novel coronavirus infections (COVID-19);Nishiura;Int J Infect Dis,2020

5. Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020;Mizumoto;Euro Surveill,2020

Cited by 51 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3