The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B

Author:

Johnson Valiente Alexandra12,Liem Kin Seng23,Schwarz Kathleen B45,Rosenthal Philip6,Murray Karen F7,Mogul Douglas5,Teckman Jeffery8,Rodriguez-Baez Norberto9,Schwarzenberg Sarah Jane10,Feld Jordan J211,Wong David K2,Lewis-Ximenez Lia L12,Lauer Georg13,Hansen Bettina E214,Ling Simon C1516,Janssen Harry L A211,Gehring Adam J1211

Affiliation:

1. Department of Immunology, University of Toronto, Ontario, Canada

2. Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada

3. Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands

4. Division of Pediatric Gastroenterology, University of California, San Diego, San Diego, California, USA

5. Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, USA

6. Department of Pediatrics, University of California, San Francisco , San Francisco, California, USA

7. Seattle Children’s Hospital, Seattle, Washington, USA

8. Department of Pediatrics, Saint Louis University, St Louis, Missouri, USA

9. Department of Pediatrics, University of Texas Southwestern, Dallas, Texas, USA

10. Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA

11. Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

12. Viral Hepatitis Laboratory, Oswaldo Cruz Institute, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

13. Massachusetts General Hospital, Boston, Massachusetts, USA

14. Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada

15. Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada

16. Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada

Abstract

Abstract Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in patients with acute hepatitis B and chronic hepatitis B with hepatitis B e antigen seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL, and TNF-α.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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