Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection-Reference-Cited by-同舟云学术

Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection

Published:1999-04-30 Issue:5415 Volume:284 Page:825-829
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Guidotti Luca G.¹,Rochford Rosemary²,Chung Josan¹,Shapiro Max³,Purcell Robert⁴,Chisari Francis V.¹

Affiliation:

1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

2. Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109–2029, USA.

3. Bioqual, Incorporated, Rockville, MD 20850, USA.

4. The National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Viral clearance during hepatitis B virus (HBV) infection has been thought to reflect the destruction of infected hepatocytes by CD8 + T lymphocytes. However, in this study, HBV DNA was shown to largely disappear from the liver and the blood of acutely infected chimpanzees long before the peak of T cell infiltration and most of the liver disease. These results demonstrate that noncytopathic antiviral mechanisms contribute to viral clearance during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm and covalently closed circular viral DNA from the nucleus of infected cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

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3. Guidotti L. G., Matzke B., Schaller H., Chisari F. V., J. Virol. 69, 6158 (1995).

4. Tuttleman J. S., Pourcel C., Summers J., Cell 47, 451 (1986).

5. Barker L. F., et al., J. Infect. Dis. 132, 451 (1975).

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