Affiliation:
1. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China
2. Food Science and Technology, Oregon State University, Corvallis, OR, USA
3. Desert Cardiology of Tucson Heart Center, Tucson, AZ, USA
Abstract
ABSTRACT
Background
Wine aged in oak barrels will incorporate polyphenols inherent in the staves, suggesting that wine stored in these wooden containers will introduce oak compounds into the human body after consumption.
Objective
The purpose of the present study is to test whether consumption of these oak compounds could favorably influence metabolism in mice fed an obesogenic diet.
Methods
C57BL/6 male mice (n = 8) were fed diets for 10 wk as follows: low-fat (LF), high-fat (HF), and HF containing 0.17% of oak tannin (HF+OT). A second 10-wk study was completed; mice were provided LF, HF, and HF diets supplemented with 7.0% of concentrates made from oaked wine (HF+OWC) or unoaked wine (HF+UWC). Physiological parameters were measured during the feeding trial and serum markers and hepatic gene expression measured from samples obtained at necropsy.
Results
Intake of HF+OT significantly reduced body-weight gain (18.4 ± 1.2 g in HF vs. 13.2 ± 1.4 g in HF+OT, P < 0.05). Serum resistin concentrations were lower in HF+OT mice compared with HF mice (301 ± 10.1 pg/mL in HF+OT vs. 374 ± 10.9 pg/mL in HF; P < 0.05). Hepatic lipid accumulation and expression of glutathione-S-transferase-m2 (Gstm2) and NAD(P)H:quinone oxidoreductase (Nqo1) mRNAs were significantly decreased in HF+OT compared with HF mice (P < 0.05). When compared with HF-fed mice, intake of both OWC and UWC decreased body-weight gain (P < 0.05), with no significant impact on food consumption. Fasting glucose concentrations, serum insulin, and hepatic lipid accumulation were reduced in HF+OWC-fed mice compared with HF+UWC-fed mice (P < 0.05). Furthermore, hepatic glutathione-S-transferase-a1 (Gsta1) mRNA levels were significantly reduced in OWC-supplemented (0.25 ± 0.08) compared with UWC-supplemented (1.71 ± 0.24) mice (P < 0.05).
Conclusions
In this mouse model of metabolic disease, intake of OTs and a concentrate made from an oaked wine had a potent impact on alleviating HF-induced metabolic syndrome. Thus, intake of OTs, provided passively in oaked wine or as a dietary supplement, may act as an agent to attenuate the markers of metabolic syndrome.
Funder
Desert Heart Foundation
Oregon Agricultural Research Foundation
Nanchang University
Publisher
Oxford University Press (OUP)
Subject
Nutrition and Dietetics,Food Science,Medicine (miscellaneous)
Reference24 articles.
1. Effects of silymarin on metabolic syndrome: a review;Vahabzadeh;J Sci Food Agric,2018
2. Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999–2010;Beltrán-Sánchez;J Am Coll Cardiol,2013
3. Metabolic syndrome: pathophysiology, management, and modulation by natural compounds;Rochlani;Ther Adv Cardiovasc Dis,2017
4. Gene expression patterns are altered in athymic mice and metabolic syndrome factors are reduced in C57BL/6J mice fed high-fat diets supplemented with soy isoflavones;Luo;J Agr Food Chem,2016
5. Development of obesity is reduced in high-fat fed mice fed whole raspberries, raspberry juice concentrate, and a combination of the raspberry phytochemicals ellagic acid and raspberry ketone;Luo;J Berry Res,2016
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献