Plasma concentrations of persistent organic pollutants and pancreatic cancer risk-Reference-Cited by-同舟云学术

Plasma concentrations of persistent organic pollutants and pancreatic cancer risk

Published:2021-07-14 Issue: Volume: Page:
ISSN:0300-5771
Container-title:International Journal of Epidemiology
language:en
Short-container-title:

Author:

Porta Miquel¹²³^ORCID,Gasull Magda¹²³,Pumarega José¹²³,Kiviranta Hannu⁴,Rantakokko Panu⁴,Raaschou-Nielsen Ole⁵,Bergdahl Ingvar A⁶⁷,Sandanger Torkjel Manning⁸,Agudo Antoni⁹,Rylander Charlotta⁸,Nøst Therese Haugdahl⁸,Donat-Vargas Carolina¹⁰¹¹,Aune Dagfinn¹²,Heath Alicia K¹²,Cirera Lluís³¹³¹⁴,Goñi-Irigoyen Fernando³¹⁵¹⁶,Alguacil Juan³¹⁷,Giménez-Robert Àlex¹²,Tjønneland Anne⁵,Sund Malin¹⁸,Overvad Kim¹⁹,Mancini Francesca Romana²⁰²¹,Rebours Vinciane²²²³,Boutron-Ruault Marie-Christine²⁰²¹,Kaaks Rudolf²⁴,Schulze Matthias B²⁵²⁶,Trichopoulou Antonia²⁷,Palli Domenico²⁸,Grioni Sara²⁹,Tumino Rosario³⁰,Naccarati Alessio³¹,Panico Salvatore³²,Vermeulen Roel³³,Quirós J Ramón³⁴,Rodríguez-Barranco Miguel³³⁴,Colorado-Yohar Sandra M³¹³³⁵,Chirlaque María-Dolores³¹³¹⁴,Ardanaz Eva³³⁶³⁷,Wareham Nick³⁸,Key Tim³⁹,Johansson Mattias⁴⁰,Murphy Neil⁴⁰,Ferrari Pietro⁴⁰,Huybrechts Inge⁴⁰,Chajes Veronique⁴⁰,Gonzalez Carlos Alberto⁹,de-Mesquita Bas Bueno-⁴¹,Gunter Marc⁴⁰,Weiderpass Elisabete⁴⁰,Riboli Elio¹²,Duell Eric J⁴²,Katzke Verena²⁴,Vineis Paolo¹²³¹^ORCID

Affiliation:

1. Hospital del Mar Institute of Medical Research (IMIM PSMar), Barcelona, Catalonia, Spain

2. Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain

3. Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain

4. Department of Health Security, National Institute for Health and Welfare, Kuopio, Finland

5. Danish Cancer Society Research Center, Copenhagen, Denmark

6. Department of Biobank Research, Umeå University, Umeå, Sweden

7. Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

8. Department of Community Medicine, UiT-The Arctic University of Norway, Tromsø, Norway

9. Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain

10. Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

11. Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, CEI UAM+CSIC, Madrid, Spain

12. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK

13. Department of Epidemiology, Murcia Regional Health Council, IMIB—Arrixaca, Murcia, Spain

14. Department of Health and Social Sciences, University of Murcia, Murcia, Spain

15. Health Department of Basque Government, Public Health Laboratory in Gipuzkoa, San Sebastian, Spain

16. Health Research Institute Biodonostia, San Sebastian, Spain

17. University of Huelva, Huelva, Spain

18. Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden

19. Department of Public Health, Aarhus University, Aarhus, Denmark

20. CESP, Faculté de médecine (USVQ), Université Paris-Sud, INSERM, Université Paris-Saclay, Villejuif, France

21. Inserm UMR1018, Institut Gustave Roussy, Villejuif, France

22. Pancreatology Department, Beaujon Hospital, AP-HP, Clichy, France

23. Inserm UMR1149, DHU Unit, Paris-Diderot University, Paris, France

24. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

25. Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam, Rehbruecke, Nuthetal, Germany

26. Institute of Nutrition Science, University of Potsdam, Nuthetal, Germany

27. Hellenic Health Foundation, Athens, Greece

28. Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network—ISPRO, Florence, Italy

29. Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

30. Cancer Registry and Histopathology Department, “Civic—M.P. Arezzo” Hospital, ASP Ragusa, Ragusa, Italy

31. Molecular and Genetic Epidemiology Unit, Italian Institute for Genomic Medicine (IIGM), Turin, Italy

32. Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy

33. Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands

34. Escuela Andaluza de Salud Pública (EASP), Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain

35. National Faculty of Public Health, University of Antioquia, Medellín, Colombia

36. Navarra Public Health Institute, Pamplona, Spain

37. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain

38. MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK

39. Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK

40. International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France

41. Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands

42. Oncology Data Analytics Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain

Abstract

Abstract Background Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts. Methods We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline. Results Some associations were observed at higher concentrations of p, p’-DDT, trans-nonachlor, β-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95% confidence interval 1.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted >6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up ≥10 years). Among participants having fasted >6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up ≥10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk. Conclusions Individually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer.

Funder

Government of Catalonia

Publisher

Oxford University Press (OUP)

Subject

General Medicine,Epidemiology

Link

https://academic.oup.com/ije/advance-article-pdf/doi/10.1093/ije/dyab115/42197971/dyab115.pdf

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