Affiliation:
1. Gastroenterology and Digestive Oncology Department Centre Hospitalier Côte Basque Bayonne France
2. ULR 2694 ‐ METRICS: Évaluation des Technologies de Santé et des Pratiques Médicales F‐59000 Lille France
3. Digestive Oncology Department CHU Reims University of Reims Champagne‐Ardenne (URCA) Reims France
4. Department of Medical Oncology Godinot Cancer Institute Reims France
5. General Digestive and Endocrine Surgery Department CHU Reims University of Reims Champagne‐Ardenne (URCA) Reims France
6. Inserm CHU Limoges Pharmacology & Toxicology U 1248 F‐87000 Limoges France
Abstract
AbstractBackgroundKnowledge about environmental pancreatic adenocarcinoma (PA) risk factors, including pesticide exposure, remains limited. Organochlorine (OC) accumulates in adipose tissue and can help reflect long‐term exposure.Patients and MethodsAge and body mass index (BMI) of patients with PA were matched with those undergoing a surgery for a benign disease on age and BMI (1:1). Targeted analyses screened 345 pesticides and metabolites, including 29 OC, in adipose tissue and urine samples. The primary aim was to investigate the association between organochlorine concentrations in visceral fat or urine, and PA. Adjusted conditional logistic regressions were carried out accounting for multiple testing.ResultsTrans‐nonachlor (odds ratio [OR] = 1.325, 95% confidence interval [CI] [1.108–1.586]), cis‐nonachlor (OR = 15.433, 95% CI [2.733–87.136]), Mirex (OR = 2.853, 95% CI [1.213–6.713]) and 4,4 DDE (OR = 1.019, 95% CI [1.005–1.034]) in fat and a greater number of positive samples (OR = 1.758 95% CI [1.11–2.997]) were significantly associated with higher odds of PA. In contrast, as awaited, urine samples did not yield any statistically significant associations for all tested pesticides.ConclusionSome OCs were associated with higher odds of PA. The underlying mechanisms of pancreatic aggression need to be investigated to refine these findings.Trial RegistrationClinicaltrials.gov NCT04429490.