BLAB2CancerKD: a knowledge graph database focusing on the association between lactic acid bacteria and cancer, but beyond

Author:

Jing Yi12ORCID,Feng Baiyang23ORCID,Gao Jing234,Li Jin23ORCID,Zhou Ganghui23,Sun Zhihong5ORCID,Wang Yufei6

Affiliation:

1. Faculty of Science, The University of New South Wales , High Street, Sydney, New South Wales 2052, Australia

2. Inner Mongolia Autonomous Region Key Laboratory of Big Data Research and Application for Agriculture and Animal Husbandry , Zhaowuda Road No. 306, Hohhot 010018, China

3. College of Computer and Information Engineering, Inner Mongolia Agricultural University , Erdos East Street No. 29, Hohhot 010011, China

4. Inner Mongolia Autonomous Region Big Data Center , Chilechuan Street No. 1, Hohhot 010091, China

5. College of Food Science and Engineering, Inner Mongolia Agricultural University , Zhaowuda Road No. 306, Hohhot 010018, China

6. The Affiliated Hospital of Inner Mongolia Medical University , Tongdao North road No.1, Hohhot 010050, China

Abstract

Abstract In a broad sense, lactic acid bacteria (LAB) is a general term for Gram-positive bacteria that can produce lactic acid by utilizing fermentable carbohydrates. It is widely used in essential fields such as industry, agriculture, animal husbandry and medicine. At the same time, LAB are closely related to human health. They can regulate human intestinal flora and improve gastrointestinal function and body immunity. Cancer, a disease in which some cells grow out of control and spread to other body parts, is one of the leading causes of human death worldwide. In recent years, the potential of LAB in cancer treatment has attracted attention. Mining knowledge from the scientific literature significantly accelerates its application in cancer treatment. Using 7794 literature studies of LAB cancer as source data, we have processed 16 543 biomedical concepts and 23 091 associations by using automatic text mining tools combined with manual curation of domain experts. An ontology containing 31 434 pieces of structured data is constructed. Finally, based on ontology, a knowledge graph (KG) database, which is called Beyond ‘Lactic acid bacteria to Cancer Knowledge graph Database’ (BLAB2CancerKD), is constructed by using KG and web technology. BLAB2CancerKD presents all the relevant knowledge intuitively and clearly in various data presentation forms, and the interactive system function also makes it more efficient. BLAB2CancerKD will be continuously updated to advance the research and application of LAB in cancer therapy. Researchers can visit BLAB2CancerKD at. Database URL http://110.40.139.2:18095/

Funder

Inner Mongolia Science and Technology Major Special Projects

Inner Mongolia Autonomous Region Graduate Research Innovation Project

Natural Science Foundation of Inner Mongolia Autonomous Region

Publisher

Oxford University Press (OUP)

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,Information Systems

Reference49 articles.

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