Elongator subunit 3 (ELP3) modifies ALS through tRNA modification-Reference-Cited by-同舟云学术

Elongator subunit 3 (ELP3) modifies ALS through tRNA modification

Published:2018-02-03 Issue:7 Volume:27 Page:1276-1289
ISSN:0964-6906
Container-title:Human Molecular Genetics
language:en
Short-container-title:

Author:

Bento-Abreu Andre¹²^ORCID,Jager Gunilla³,Swinnen Bart¹²⁴,Rué Laura¹²,Hendrickx Stijn⁵,Jones Ashley⁶,Staats Kim A¹²^ORCID,Taes Ines¹²,Eykens Caroline¹²,Nonneman Annelies¹²,Nuyts Rik¹²,Timmers Mieke¹²,Silva Lara¹²,Chariot Alain⁷,Nguyen Laurent⁸,Ravits John⁹,Lemmens Robin¹²⁴,Cabooter Deirdre⁵,Van Den Bosch Ludo¹²,Van Damme Philip¹²⁴,Al-Chalabi Ammar⁶,Bystrom Anders³,Robberecht Wim¹⁴

Affiliation:

1. Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), KU Leuven—University of Leuven, B-3000 Leuven, Belgium

2. Laboratory of Neurobiology, VIB—Center for Brain & Disease Research, B-3000 Leuven, Belgium

3. Department of Molecular Biology, Umeå University, Umeå 901 87, Sweden

4. Department of Neurology, University Hospitals Leuven, B-3000 Leuven, Belgium

5. Department of Pharmaceutical & Pharmacological Sciences, Pharmaceutical Analysis, B-3000 Leuven, Belgium

6. Department of Clinical Neuroscience, Institute of Psychiatry, King’s College London, London SE5 8AF, UK

7. GIGA-Molecular Biology of Diseases and Walloon Excellence in Life Sciences and Biotechnology (WELBIO), C.H.U. Sart Tilman, B-4000 Liège, Belgium

8. GIGA-Neurosciences, University of Liège, C.H.U. Sart Tilman, B-4000 Liège, Belgium

9. Department of Neurosciences, ALS Translational Research, University of California, San Diego, La Jolla, CA, USA

Funder

Economic and Social Research Council

Research Foundation Flanders

Belgian Federal Science Policy Office

Association Belge contre les Maladies Neuro-Musculaires

National Institute for Health Research

NIHR

South London and Maudsley NHS Foundation Trust

King’s College London

Swedish Research Council

European Commission

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

Link

http://academic.oup.com/hmg/article-pdf/27/7/1276/24398965/ddy043.pdf

Reference43 articles.

1. The changing scene of amyotrophic lateral sclerosis;Robberecht;Nat. Rev. Neurosci,2013

2. The phenotypic variability of amyotrophic lateral sclerosis;Swinnen;Nat. Rev. Neurol,2014

3. Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration;Simpson;Hum. Mol. Genet,2009

4. Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene;van Blitterswijk;Mol. Neurodegener,2014

5. An early step in wobble uridine tRNA modification requires the Elongator complex;Huang;RNA,2005

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