Teicoplanin Therapeutic Drug Monitoring and Treatment Outcomes in Children With Gram-Positive Infections

Author:

Loane Georgia1ORCID,Gwee Amanda123

Affiliation:

1. Department of General Medicine, The Royal Children’s Hospital Melbourne, Parkville, Victoria, Australia

2. Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia

3. Infectious Diseases Group, Murdoch Children’s Research Institute, Parkville, Victoria, Australia

Abstract

Abstract This is a retrospective audit of teicoplanin dosing, drug-level monitoring, and outcomes in 29 children who received 31 courses of teicoplanin. Our study of noncritically ill children showed that the majority (35/43, 81%) of trough concentrations were within the therapeutic range (10-30 mg/L) contrasting previous studies in children. Overall, 21 of the 24 (88%) children with Gram-positive infections achieved cure.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

Reference19 articles.

1. Teicoplanin versus vancomycin for proven or suspected infection;Cavalcanti;Cochrane Database Syst Rev,2010

2. Treatment of endocarditis with teicoplanin: a retrospective analysis of 104 cases;Wilson;J Antimicrob Chemother,1996

3. Teicoplanin therapy for Staphylococcus aureus septicaemia: relationship between pre-dose serum concentrations and outcome;Harding;J Antimicrob Chemother,2000

4. Population pharmacokinetics of teicoplanin in children;Ramos-Martín;Antimicrob Agents Chemother,2014

5. Population pharmacokinetics and dosing optimization of teicoplanin in children with malignant haematological disease;Zhao;Br J Clin Pharmacol,2015

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