Improved Treatment Outcomes With Bedaquiline When Substituted for Second-line Injectable Agents in Multidrug-resistant Tuberculosis: A Retrospective Cohort Study

Author:

Zhao Ying1,Fox Tamaryn1,Manning Kathryn1,Stewart Annemie2,Tiffin Nicki345,Khomo Ntokozo1,Leslie Joshua1,Boulle Andrew3,Mudaly Vanessa6,Kock Yulene6,Meintjes Graeme15,Wasserman Sean15ORCID

Affiliation:

1. Department of Medicine, University of Cape Town, Cape Town, South Africa

2. Clinical Research Centre, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

3. Provincial Health Data Centre, Western Cape Department of Health and Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa

4. Computational Biology, Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa

5. Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa

6. Department of Health, Provincial Government of the Western Cape, Cape Town, South Africa

Funder

Wellcome Trust

South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation

European & Developing Countries Clinical Trials Partnership

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference24 articles.

1. Adverse events in the treatment of multidrug-resistant tuberculosis: results from the DOTS-Plus initiative;Nathanson;Int J Tuberc Lung Dis,2004

2. Drug-associated adverse events and their relationship with outcomes in patients receiving treatment for extensively drug-resistant tuberculosis in South Africa;Shean;PLoS One,2013

3. Resistance to fluoroquinolones and second-line injectable drugs: impact on multidrug-resistant TB outcomes;Falzon;Eur Respir J,2013

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