The Nucleic Acid Knowledgebase: a new portal for 3D structural information about nucleic acids

Author:

Lawson Catherine L12ORCID,Berman Helen M234,Chen Li12,Vallat Brinda12,Zirbel Craig L5

Affiliation:

1. Institute for Quantitative Biomedicine, Rutgers, State University of New Jersey , 174 Frelinghuysen Road , Piscataway , NJ  08854 , USA

2. Research Collaboratory for Structural Bioinformatics Protein Data Bank, Rutgers, The State University of New Jersey , Piscataway , NJ  08854 , USA

3. Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey , Piscataway , NJ  08854 , USA

4. Department of Quantitative and Computational Biology, University of Southern California , Los Angeles , CA  90089 , USA

5. Department of Mathematics and Statistics, Bowling Green State University , Bowling Green , OH  43403 , USA

Abstract

Abstract The Nucleic Acid Knowledgebase (nakb.org) is a new data resource, updated weekly, for experimentally determined 3D structures containing DNA and/or RNA nucleic acid polymers and their biological assemblies. NAKB indexes nucleic acid-containing structures derived from all major structure determination methods (X-ray, NMR and EM), including all held by the Protein Data Bank (PDB). As the planned successor to the Nucleic Acid Database (NDB), NAKB’s design preserves all functionality of the NDB and provides novel nucleic acid-centric content, including structural and functional annotations, as well as annotations from and links to external resources. A variety of custom interactive tools have been developed to enable rapid exploration and drill-down of NAKB’s content.

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Genetics

Reference47 articles.

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