Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities

Author:

Mainland Joel D1ORCID,Barlow Linda A2,Munger Steven D3ORCID,Millar Sarah E4,Vergara M Natalia5,Jiang Peihua1,Schwob James E6,Goldstein Bradley J7,Boye Shannon E8,Martens Jeffrey R3,Leopold Donald A9,Bartoshuk Linda M10,Doty Richard L11,Hummel Thomas12ORCID,Pinto Jayant M13,Trimmer Casey14,Kelly Christine15,Pribitkin Edmund A16,Reed Danielle R1

Affiliation:

1. Monell Chemical Senses Center, Philadelphia, PA, USA

2. Department of Cell & Developmental Biology, Rocky Mountain Taste and Smell Center, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA

3. Center for Smell and Taste, Department of Pharmacology and Therapeutics, 1200 Newell Drive, University of Florida, Gainesville, FL, USA

4. Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

5. Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado School of Medicine, Aurora, CO, USA

6. Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA

7. Department of Head and Neck Surgery and Communication Sciences, Duke University School of Medicine, 40 Duke Medicine Cir Clinic 1F, Durham, NC, USA

8. Department of Ophthalmology, University of Florida College of Medicine, Gainesville, FL, USA

9. Division of Otolaryngology Head and Neck Surgery, University of Vermont Medical Center, Burlington, VT, USA

10. Department of Food Science and Human Nutrition, Center for Smell and Taste, University of Florida, Gainesville, FL, USA

11. Smell and Taste Center and Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, 3400 Spruce Street, University of Pennsylvania, Philadelphia, PA, USA

12. Department of Otorhinolaryngology, Smell and Taste Clinic, Technische Universität Dresden, Fetscherstrasse, Dresden, Germany

13. Section of Otolaryngology—Head and Neck Surgery, Department of Surgery, The University of Chicago, MC, Chicago, IL, USA

14. Firmenich Inc., Plainsboro, NJ, USA

15. AbScent, Andover, Hampshire, UK

16. Department of Otolaryngology—Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PA, USA

Abstract

Abstract The chemical senses of taste and smell play a vital role in conveying information about ourselves and our environment. Tastes and smells can warn against danger and also contribute to the daily enjoyment of food, friends and family, and our surroundings. Over 12% of the US population is estimated to experience taste and smell (chemosensory) dysfunction. Yet, despite this high prevalence, long-term, effective treatments for these disorders have been largely elusive. Clinical successes in other sensory systems, including hearing and vision, have led to new hope for developments in the treatment of chemosensory disorders. To accelerate cures, we convened the “Identifying Treatments for Taste and Smell Disorders” conference, bringing together basic and translational sensory scientists, health care professionals, and patients to identify gaps in our current understanding of chemosensory dysfunction and next steps in a broad-based research strategy. Their suggestions for high-yield next steps were focused in 3 areas: increasing awareness and research capacity (e.g., patient advocacy), developing and enhancing clinical measures of taste and smell, and supporting new avenues of research into cellular and therapeutic approaches (e.g., developing human chemosensory cell lines, stem cells, and gene therapy approaches). These long-term strategies led to specific suggestions for immediate research priorities that focus on expanding our understanding of specific responses of chemosensory cells and developing valuable assays to identify and document cell development, regeneration, and function. Addressing these high-priority areas should accelerate the development of novel and effective treatments for taste and smell disorders.

Funder

Kerry Group

Monell Chemical Senses Center

Sensonics Inc.

National Institute on Deafness and Other Communication Disorders

Publisher

Oxford University Press (OUP)

Subject

Behavioral Neuroscience,Physiology (medical),Sensory Systems,Physiology

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