Superparamagnetic iron oxide nanoparticle regulates microbiota–gut–inner ear axis for hearing protection

Author:

Guo Zhanhang1,Wu Yunhao23,Chen Bo4,Kong Mengdie3,Xie Peng3,Li Yan1,Liu Dongfang5,Chai Renjie3678910,Gu Ning111

Affiliation:

1. Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University , Nanjing 210009 , China

2. Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences , Jinan 250000 , China

3. State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University , Nanjing 210096 , China

4. Institute of Materials Science and Devices, School of Materials Science and Engineering, Suzhou University of Science and Technology , Suzhou 215009 , China

5. Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology & Vascular Surgery, Department of Radiology, Medical School, Zhongda Hospital, Southeast University , Nanjing 210009 , China

6. Co-Innovation Center of Neuroregeneration, Nantong University , Nantong 226001 , China

7. School of Medical Technology, Institute of Engineering Medicine, Beijing Institute of Technology , Beijing 100081 , China

8. Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu 610072 , China

9. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences , Beijing 100101 , China

10. Southeast university Shenzhen research institute , Shenzhen 518063 , China

11. Cardiovascular Disease Research Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Medical School, Nanjing University , Nanjing 210093 , China

Abstract

ABSTRACT Noise-induced hearing loss (NIHL) is a highly prevalent form of sensorineural hearing damage that has significant negative effects on individuals of all ages and there are no effective drugs approved by the US Food and Drug Administration. In this study, we unveil the potential of superparamagnetic iron oxide nanoparticle assembly (SPIOCA) to reshape the dysbiosis of gut microbiota for treating NIHL. This modulation inhibits intestinal inflammation and oxidative stress responses, protecting the integrity of the intestinal barrier. Consequently, it reduces the transportation of pathogens and inflammatory factors from the bloodstream to the cochlea. Additionally, gut microbiota-modulated SPIOCA-induced metabolic reprogramming in the gut–inner ear axis mainly depends on the regulation of the sphingolipid metabolic pathway, which further contributes to the restoration of hearing function. Our study confirms the role of the microbiota–gut–inner ear axis in NIHL and provides a novel alternative for the treatment of NIHL and other microbiota dysbiosis-related diseases.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Nanjing Science and Technology Development Foundation

Key Research and Development Program of Jiangsu Province

Science and Technology Department of Sichuan Province

Shenzhen Science and Technology Program

Guangdong Academy of Medical Sciences

Natural Science Foundation for Excellent Youth Scholars of Jiangsu Science

Publisher

Oxford University Press (OUP)

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