Akirin/Subolesin regulatory mechanisms at host/tick–pathogen interactions

Author:

de la Fuente José12ORCID,Artigas-Jerónimo Sara1,Villar Margarita13

Affiliation:

1. SaBio, Instituto de Investigacion en Recursos Cinegeticos IREC-CSIC-UCLM-JCCM, 13005 Ciudad Real, Spain

2. Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA

3. Biochemistry Section, Faculty of Science and Chemical Technologies, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha, 13071 Ciudad Real, Spain

Abstract

ABSTRACT Ticks and tick-borne pathogens such as Anaplasma phagocytophilum affect human and animal health worldwide and thus the characterization of host/tick–pathogen interactions is important for the control of tick-borne diseases. The vertebrate regulatory proteins Akirins and its tick ortholog, Subolesin, are conserved throughout the metazoan and involved in the regulation of different biological processes such as immune response to pathogen infection. Akirin/Subolesin have a key role in host/tick–pathogen interactions and exert its regulatory function primarily through interacting proteins such as transcription factors, chromatin remodelers and RNA-associated proteins. Recent results have provided evidence of akirin/subolesin genetic interactions and the interaction of Akirin/Subolesin with histones, thus suggesting a role in direct chromatin remodeling. Finally, and still to be proven, some models suggest the possibility of direct Akirin/Subolesin protein interactions with DNA. Future research should advance the characterization of Akirin/Subolesin interactome and its functional role at the host/tick–pathogen interface. These results have implications for translational biotechnology and medicine for the development of new effective interventions for the control of ticks and tick-borne diseases.

Funder

Ministerio de Ciencia e Innovación

Agencia Estatal de Investigación

ERDF

CSIC

UCLM

Publisher

Oxford University Press (OUP)

Subject

General Medicine

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