Association of anaemia, co-morbidities and red blood cell transfusion according to age groups: multicentre sub-analysis of the German Patient Blood Management Network Registry
Author:
Blum Lea Valeska1, Schmitt Elke12, Choorapoikayil Suma1, Baumhove Olaf3, Bayer Alexandra4, Friederich Patrick5, Friedrich Jens6, Geisen Christof7, Gruenewald Matthias8, Gutjahr Martin9, Herrmann Eva2ORCID, Müller Markus7, Narita Diana10, Raadts Ansgar11, Schwendner Klaus12, Seifried Erhard7, Stark Patrick13, Thoma Josef14, Weigt Henry15, Wiesenack Christoph16, Steinbicker Andrea Ulrike117, Zacharowski Kai1, Meybohm Patrick118, Baumhove O, de Leeuw van Weenen S, Narita D, Huber J M, Adam E, Choorapoikayil S, Hof L, Isik S, Krämer M, Neb H, Neef V, Piekarski F, Schmitt E, Zacharowski K, Walther T, Holubec T, Schnitzbauer A, Bechstein W O, Derwich W, Schmitz-Rixen T, Steffen B, Serve H, Bojunga J, Zeuzem S, Konczalla J, Seifert V, Roos F, Chun F, Nau C, Marzi I, Leinung M, Stöver T, Ghanaati S, Sader R, Louwen F, Becker S, Ernst J, Sauter Joachim, Wiesenack C, Gerber M, Bayer A, Weigt H, Raadts A, Duemmler J, Gruenewald M, Hummitzsch Lars, Lorenzen U, Renner J, Sokirjanski M, Steinfath M, Pagel M, Haneya A, Puehler T, Berndt R, Rusch R, Becker T, Pochhammer J, Klueter T, Seekamp A, Ahmeti H, Helmers A, Osmonow Daniar, Bauerschlag Dirk, Wieker Henning, Hoffmann Markus, Friedrich J, Molter Gerd, Bier M, Gutjahr M, Bauer R, Bräutigam B, Friederich P, Van Aken H K, Boanta A, Becker J, Bomert M, Bueckmann A, Boerner K, Ceanga A, Cortés M Nunez, Duran I, Fraune T, Gallaby R, Goncalves D, Heßler Ml, Hawari M, Jenke D J, Kieserling K, Korhonen J, Krycki J, Lehmann F, Maeßen T, Mocanu V, Naber Pk, Opas Sn, Peters F, Rauer M, Rieder H, Van Ohlen R, Schilling B, Scholle D, Schulz J, Schwellenbach D, Steinbicker A U, Thoene I, Ueding A, Varelas G, Warnken L, Wempe C, Wisudanto I, Zarbock A, Zurheiden N, Stummer W, Brokinkel B, Martens S, Senniger N, Wolters H, Pascher A, Gosheger G, Moellenbeck B, Deventer N, Oberhuber A, Kasprzak B, Herrmann E, Schrader A, Kiesel L, Kleinheinz J, Koesters C, Raschke M J, Latal T, Niehoff D, Geissler R G, Hillmann H, Stelljes M, Kerkhoff A, Berdel W, Lenz G, Schwendner K, Thoma J, Helmer P, Hottenrott S, Kranke P, Meybohm P, Roeder D, Schlesinger T, Sitter M, Stumpner J, Stark P,
Affiliation:
1. Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University , Frankfurt , Germany 2. Department of Medicine, Institute of Biostatistics and Mathematical Modelling, Goethe University , Frankfurt , Germany 3. Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Klinikum Westmuensterland , Bocholt , Germany 4. Department of Anaesthesiology and Intensive Care Medicine, Agatharied Hospital , Hausham , Germany 5. Department of Anaesthesiology, Operative Intensive Care Medicine and Pain Therapy , Munich , Germany 6. Department of Anaesthesiology and Intensive Care Medicine, Klinikum Leverkusen , Leverkusen , Germany 7. German Red Cross, Institute for Transfusion Medicine and Immunohaematology, German Red Cross Baden-Wuertemberg–Hessen, Goethe University Frankfurt , Frankfurt am Main , Germany 8. Department of Anaesthesiology and Operative Intensive Care Medicine, University Hospital Schleswig-Holstein , Kiel , Germany 9. Department of Anaesthesiology, Marienhaus , Ottweiler , Germany 10. Institute for Laboratory Diagnostics and Transfusion Medicine, Donauisarklinikum , Deggendorf , Germany 11. Department of Anaesthesiology and Intensive Care Medicine, University Hospital Jena , Jena , Germany 12. Department of Anaesthesiology and Operative Intensive Care Medicine, Diakonie Hospital Martha-Maria , Nuremberg , Germany 13. Department of Visceral and Vascular Surgery, Klinikum Mittelmosel , Zell , Germany 14. Department of Anaesthesiology and Operative Intensive Care Medicine, Ortenauklinikum , Gengenbach , Germany 15. Department of Anaesthesiology, SLK-Kliniken , Heilbronn , Germany 16. Department of Anaesthesiology, Evangelisches Diakoniekrankenhaus Freiburg , Freiburg , Germany 17. Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster , Muenster , Germany 18. Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg , Wuerzburg , Germany
Abstract
Abstract
Background
Blood transfusions are common medical procedures and every age group requires detailed insights and treatment bundles. The aim of this study was to examine the association of anaemia, co-morbidities, complications, in-hospital mortality, and transfusion according to age groups to identify patient groups who are particularly at risk when undergoing surgery.
Methods
Data from 21 Hospitals of the Patient Blood Management Network Registry were analysed. Patients were divided into age subgroups. The incidence of preoperative anaemia, co-morbidities, surgical disciplines, hospital length of stay, complications, in-hospital mortality rate, and transfusions were analysed by descriptive and multivariate regression analysis.
Results
A total of 1 117 919 patients aged 18–108 years were included. With increasing age, the number of co-morbidities and incidence of preoperative anaemia increased. Complications, hospital length of stay, and in-hospital mortality increased with age and were higher in patients with preoperative anaemia. The mean number of transfused red blood cells (RBCs) peaked, whereas the transfusion rate increased continuously. Multivariate regression analysis showed that increasing age, co-morbidities, and preoperative anaemia were independent risk factors for complications, longer hospital length of stay, in-hospital mortality, and the need for RBC transfusion.
Conclusion
Increasing age, co-morbidities, and preoperative anaemia are independent risk factors for complications, longer hospital length of stay, in-hospital mortality, and the need for RBC transfusion. Anaemia diagnosis and treatment should be established in all patients.
Publisher
Oxford University Press (OUP)
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|