Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide

Author:

Loperena Roxana1,Van Beusecum Justin P2,Itani Hana A2,Engel Noah3,Laroumanie Fanny2,Xiao Liang2,Elijovich Fernando2,Laffer Cheryl L2,Gnecco Juan S4,Noonan Jonathan5,Maffia Pasquale567,Jasiewicz-Honkisz Barbara89,Czesnikiewicz-Guzik Marta6,Mikolajczyk Tomasz89,Sliwa Tomasz89,Dikalov Sergey2,Weyand Cornelia M10,Guzik Tomasz J6,Harrison David G12

Affiliation:

1. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA

2. Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

3. Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA

4. Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA

5. Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, UK

6. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK

7. Department of Pharmacy, University of Naples Federico II, Naples, Italy

8. Department of Internal Medicine, Jagiellonian University School of Medicine, Cracow, Poland

9. Department of Immunology, Jagiellonian University School of Medicine, Cracow, Poland

10. Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA

Funder

National Heart and Blood Institute

National Institutes of Health

American Heart Association Strategically Focused Research Network

National Heart, Lung, and Blood Institute

Ruth L. Kirschstein National Research Service Award

NRSA

Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research

Engineering and Physical Sciences Research Council

EPSRC

British Heart Foundation

Wellcome Trust Senior Biomedical Fellowship

National Science Centre of Poland

BHF Centre of Research Excellence

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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