The Generalized Pustular Psoriasis Physician Global Assessment (GPPGA) score: online assessment and validation study of a specific measure of GPP disease activity

Author:

Burden A David1ORCID,Bachelez Hervé23ORCID,Choon Siew Eng4ORCID,Marrakchi Slaheddine5,Tsai Tsen-Fang6ORCID,Turki Hamida5,Morita Akimichi7,Lebwohl Mark G8,Bissonnette Robert9,Zheng Min10,Anadkat Milan J11,Navarini Alexander A12ORCID,Tang Ming13ORCID,Thoma Christian14,Duffin Kristina Callis15

Affiliation:

1. Institute of Infection, Immunity and Inflammation, University of Glasgow , Glasgow , UK

2. Service de Dermatologie, Assistance Publique-Hôpitaux de Paris Hôpital Saint-Louis , Paris , France

3. INSERM U1163, Imagine Institute for Genetics of Human Diseases, Université Paris Cité , Paris , France

4. Department of Dermatology, Hospital Sultanah Aminah, Clinical School Johor Bahru, Monash University Malaysia , Subang Jaya , Malaysia

5. Department of Dermatology, Hedi Chaker Hospital, University of Sfax , Sfax , Tunisia

6. Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine , Taipei , Taiwan

7. Department of Geriatric and Environmental Dermatology, Nagoya City University, Graduate School of Medical Sciences , Nagoya , Japan

8. Icahn School of Medicine at Mount Sinai , New York, NY , USA

9. Innovaderm Research Inc. , Montreal, Quebec , Canada

10. Department of Dermatology, Second Affiliated Hospital, Zhejiang University, School of Medicine , Hangzhou, Zhejiang , China

11. Washington University School of Medicine, Division of Dermatology , St Louis, MO , USA

12. Department of Dermatology, University Hospital Basel , Basel , Switzerland

13. Boehringer Ingelheim (China) Investment Co. Ltd , Shanghai , China

14. Boehringer Ingelheim International GmbH , Biberach , Germany

15. Department of Dermatology, University of Utah , Salt Lake City, Utah , USA

Abstract

Generalized pustular psoriasis (GPP), a rare and potentially life-threatening neutrophilic skin disease, is characterized by recurrent flares of pustulation on nonacral skin with associated erythema, crusting and scaling. There are no agreed or validated measurements for assessing GPP severity or symptom improvement; clinically validated endpoints that incorporate key manifestations of GPP, and are meaningful and reliable for the evaluation of treatment response, are needed.

Funder

Boehringer Ingelheim

International Committee of Medical Journal Editors

Publisher

Oxford University Press (OUP)

Subject

Dermatology

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