Considerations for defining and diagnosing generalized pustular psoriasis

Author:

Prajapati Vimal H.12345ORCID,Lynde Charles W.6ORCID,Gooderham Melinda J.7ORCID,Hong H. Chih‐ho89ORCID,Kirchhof Mark G.10ORCID,Lansang Perla11121314,Ringuet Julien15ORCID,Turchin Irina1617ORCID,Vender Ron1819ORCID,Yeung Jensen2021ORCID,Papp Kim A.202223ORCID

Affiliation:

1. Division of Dermatology, Department of Medicine University of Calgary Calgary Alberta Canada

2. Section of Community Pediatrics, Department of Pediatrics University of Calgary Calgary Alberta Canada

3. Section of Pediatric Rheumatology, Department of Pediatrics University of Calgary Calgary Alberta Canada

4. Dermatology Research Institute Calgary Alberta Canada

5. Skin Health & Wellness Centre Calgary Alberta Canada

6. Lynde Dermatology, Probity Medical Research, Markham and Department of Medicine University of Toronto Toronto Ontario Canada

7. SKiN Health, Probity Medical Research Queen's University Peterborough Ontario Canada

8. Division of Dermatology and Skin Science University of British Columbia Surrey British Columbia Canada

9. Probity Medical Research Inc. Surrey British Columba Canada

10. Division of Dermatology, Faculty of Medicine University of Ottawa, and the Ottawa Hospital Ottawa Ontario Canada

11. Division of Dermatology, Faculty of Medicine University of Toronto Toronto Ontario Canada

12. Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre University of Toronto Toronto Ontario Canada

13. Division of Dermatology Women's College Hospital Toronto Ontario Canada

14. The Hospital for Sick Children Toronto Ontario Canada

15. Centre de Recherche Dermatologique du Québec (CRDQ) Québec Quebec Canada

16. Brunswick Dermatology Center and Probity Medical Research Fredericton New Brunswick Canada

17. Department of Medicine Dalhousie University Halifax Nova Scotia Canada

18. Division of Dermatology, Department of Medicine McMaster University Hamilton Ontario Canada

19. Dermatrials Research Inc. Hamilton Ontario Canada

20. Division of Dermatology, Department of Medicine University of Toronto Toronto Ontario Canada

21. Probity Medical Research Inc. Toronto Ontario Canada

22. Probity Medical Research Inc. Waterloo Ontario Canada

23. Alliance Clinical Trials Waterloo Ontario Canada

Abstract

AbstractGeneralized pustular psoriasis (GPP) is a rare, chronic skin disease, characterized by widespread pustules and erythema, often accompanied with systemic signs and symptoms. GPP flares occur episodically but may be protracted. Left untreated, GPP can be life‐threatening. Despite being first reported over 100 years ago, definitions and diagnostic criteria for GPP have been inconsistent and varied due, in part, to its rarity and a limited understanding of its pathogenesis. As such, many patients with GPP face delays in diagnosis and subsequent treatment. This manuscript aims to increase the recognition of GPP and provide foundational considerations to aid in the definition and diagnosis of this disease.

Funder

Boehringer Ingelheim

Publisher

Wiley

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