The InterPro protein families and domains database: 20 years on-Reference-Cited by-全球学者库

The InterPro protein families and domains database: 20 years on

Published:2020-11-06 Issue:D1 Volume:49 Page:D344-D354
ISSN:0305-1048
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Blum Matthias¹^ORCID,Chang Hsin-Yu¹,Chuguransky Sara¹^ORCID,Grego Tiago¹,Kandasaamy Swaathi¹,Mitchell Alex¹^ORCID,Nuka Gift¹,Paysan-Lafosse Typhaine¹,Qureshi Matloob¹^ORCID,Raj Shriya¹^ORCID,Richardson Lorna¹^ORCID,Salazar Gustavo A¹,Williams Lowri¹^ORCID,Bork Peer²,Bridge Alan³,Gough Julian⁴,Haft Daniel H⁵,Letunic Ivica⁶^ORCID,Marchler-Bauer Aron⁵,Mi Huaiyu⁷,Natale Darren A⁸,Necci Marco⁹,Orengo Christine A¹⁰,Pandurangan Arun P⁴,Rivoire Catherine³,Sigrist Christian J A³,Sillitoe Ian¹⁰^ORCID,Thanki Narmada⁵,Thomas Paul D⁷^ORCID,Tosatto Silvio C E⁹^ORCID,Wu Cathy H⁸,Bateman Alex¹^ORCID,Finn Robert D¹^ORCID

Affiliation:

1. European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK

2. European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany

3. Swiss-Prot Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, CH-1211, Geneva 4, Switzerland

4. Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Ave, Trumpington, Cambridge CB2 0QH, UK

5. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda MD 20894 USA

6. Biobyte Solutions GmbH, Bothestr 142, 69126 Heidelberg, Germany

7. Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA

8. Protein Information Resource, Georgetown University Medical Center, Washington, DC 20007, USA

9. Department of Biomedical Sciences, University of Padua, via U. Bassi 58/b, 35131 Padua, Italy

10. Department of Structural and Molecular Biology, University College London, Gower St, Bloomsbury, London WC1E 6BT, UK

Abstract

Abstract The InterPro database (https://www.ebi.ac.uk/interpro/) provides an integrative classification of protein sequences into families, and identifies functionally important domains and conserved sites. InterProScan is the underlying software that allows protein and nucleic acid sequences to be searched against InterPro's signatures. Signatures are predictive models which describe protein families, domains or sites, and are provided by multiple databases. InterPro combines signatures representing equivalent families, domains or sites, and provides additional information such as descriptions, literature references and Gene Ontology (GO) terms, to produce a comprehensive resource for protein classification. Founded in 1999, InterPro has become one of the most widely used resources for protein family annotation. Here, we report the status of InterPro (version 81.0) in its 20th year of operation, and its associated software, including updates to database content, the release of a new website and REST API, and performance improvements in InterProScan.

Funder

Wellcome

Biotechnology and Biological Sciences Research Council

National Science Foundation

Division of Biological Infrastructure

ELIXIR

Open Targets

European Molecular Biology Laboratory

National Institutes of Health

DHHS

Publisher

Oxford University Press (OUP)