The kinase module of the Mediator complex: an important signalling processor for the development and survival of plants

Author:

Agrawal Rekha1,Jiří Fajkus2,Thakur Jitendra K1ORCID

Affiliation:

1. Plant Mediator Lab, National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi, India

2. Mendel Centre for Plant Genomics and Proteomics, Central European Institute of Technology, Masaryk University, Brno, Czech Republic

Abstract

AbstractMediator, a multisubunit protein complex, is a signal processor that conveys regulatory information from transcription factors to RNA polymerase II and therefore plays an important role in the regulation of gene expression. This megadalton complex comprises four modules, namely, the head, middle, tail, and kinase modules. The first three modules form the core part of the complex, whereas association of the kinase module is facultative. The kinase module is able to alter the function of Mediator and has been established as a major transcriptional regulator of numerous developmental and biochemical processes. The kinase module consists of MED12, MED13, CycC, and kinase CDK8. Upon association with Mediator, the kinase module can alter its structure and function dramatically. In the past decade, research has established that the kinase module is very important for plant growth and development, and in the fight against biotic and abiotic challenges. However, there has been no comprehensive review discussing these findings in detail and depth. In this review, we survey the regulation of kinase module subunits and highlight their many functions in plants. Coordination between the subunits to process different signals for optimum plant growth and development is also discussed.

Funder

Science and Engineering Research Board

Department of Science and Technology, Government of India

Council of Scientific and Industrial Research, Government of India

INTER-COST

European Regional Development Fund

Publisher

Oxford University Press (OUP)

Subject

Plant Science,Physiology

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