Conserved Structures of Mediator and RNA Polymerase II Holoenzyme-Reference-Cited by-同舟云学术

Conserved Structures of Mediator and RNA Polymerase II Holoenzyme

Published:1999-02-12 Issue:5404 Volume:283 Page:985-987
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Asturias Francisco J.¹,Jiang Yi Wei¹,Myers Lawrence C.¹,Gustafsson Claes M.¹,Kornberg Roger D.¹

Affiliation:

1. Department of Structural Biology, Fairchild Building, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Single particles of the mediator of transcriptional regulation (Mediator) and of RNA polymerase II holoenzyme were revealed by electron microscopy and image processing. Mediator alone appeared compact, but at high pH or in the presence of RNA polymerase II it displayed an extended conformation. Holoenzyme contained Mediator in a fully extended state, partially enveloping the globular polymerase, with points of apparent contact in the vicinity of the polymerase carboxyl-terminal domain and the DNA-binding channel. A similarity in appearance and conformational behavior of yeast and murine complexes indicates a conservation of Mediator structure among eukaryotes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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