Affiliation:
1. Department of Oral Rehabilitation & Biosciences, School of Dentistry, Oregon Health & Science University , 3181 Sam Jackson Park Road, Portland, OR 97202 , United States
2. Genomic Medicine Group, J. Craig Venter Institute , La Jolla, CA 92037 , United States
3. Department of Pediatrics, UC San Diego School of Medicine , La Jolla, CA 92093 , United States
Abstract
Abstract
The oral microbiota has an enormous impact on human health, with oral dysbiosis now linked to many oral and systemic diseases. Recent advancements in sequencing, mass spectrometry, bioinformatics, computational biology, and machine learning are revolutionizing oral microbiome research, enabling analysis at an unprecedented scale and level of resolution using omics approaches. This review contains a comprehensive perspective of the current state-of-the-art tools available to perform genomics, metagenomics, phylogenomics, pangenomics, transcriptomics, proteomics, metabolomics, lipidomics, and multi-omics analysis on (all) microbiomes, and then provides examples of how the techniques have been applied to research of the oral microbiome, specifically. Key findings of these studies and remaining challenges for the field are highlighted. Although the methods discussed here are placed in the context of their contributions to oral microbiome research specifically, they are pertinent to the study of any microbiome, and the intended audience of this includes researchers would simply like to get an introduction to microbial omics and/or an update on the latest omics methods. Continued research of the oral microbiota using omics approaches is crucial and will lead to dramatic improvements in human health, longevity, and quality of life.
Funder
National Institute of Dental and Craniofacial Research
Research Council of Norway
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Microbiology
Cited by
1 articles.
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