Clinical Criteria of Central Sensitization in Chronic Pelvic and Perineal Pain (Convergences PP Criteria): Elaboration of a Clinical Evaluation Tool Based on Formal Expert Consensus

Author:

Levesque Amélie1ORCID,Riant Thibault12,Ploteau Stéphane13,Rigaud Jérôme1,Labat Jean-Jacques1,Amarenco Gérard4,Attal Nadine5,Bautrant Eric6,Marc Beer Gabel7,Cervigni Mauro8,Chelimsky Thomas9,Farmer Melissa10,Adela Giamberardino Maria11,Greenslade Gareth12,Hughes John13,Lord Marie Josée14,Marchand Serge15,Messelink Bert16,Moyal Barracco Micheline17,Tu Franck F18,Usandizaga Elio Ràmon19,Vancaillie Thierry20,Vincent Katy21,Watier Alain22,

Affiliation:

1. Federative Pelvic Pain Center, Department of Urology, Nantes University Hospital, Nantes, France

2. Department of Pain Management, Maurice Bensignor Multidisciplinary Pain Center, Centre Catherine de Sienne, Nantes, France

3. Department of Gynecology-Obstetrics and Reproductive Medicine, Nantes University Hospital, Nantes, France

4. Group of Clinical Research in Neuro-Urology and AP-HP, Hôpital Tenon, Service de Neuro-Urologie, Paris

5. INSERM U-987, Hôpital Ambroise Paré, Boulogne-Billancourt and Université Versailles-Saint-Quentin

6. Pelvi-Perineal Surgery and Rehabilitation Department, Private Medical Centre “L’Avancée - Clinique Axium” Aix-en-Provence

7. Neurogastroenterology and Pelvic Floor Unit Sheba Medical Center, Tel Hashomer, Israel

8. Interstitial Cystitis Referral Center & Female Pelvic Medicine & Reconstructive Surgery Center Foundation University Hospital A. Gemelli, Catholic University, Rome

9. Neurology Department, Medical College of Wisconsin

10. Feinberg School of Medicine, Department of Physiology, Northwestern University, Chicago

11. Geriatrics Clinic, Fibromyalgia and Headache Center, Department of Medicine and Science of Aging, “G. D’Annunzio” University of Chieti, Chieti

12. Department of Anaesthesia, Frenchay Hospital, Bristol

13. Pain Management Unit, The James Cook University Hospital, Middlesbrough

14. Physio Santé Pelvienne and Pelvic Floor Instructor at Physio Uro-Santé, Montréal

15. Neurosurgery Department, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke

16. Department of Urology, University of Groningen Groningen, Netherland

17. Hôpital Tarnier-Cochin, Service de Dermatologie, Paris

18. Dept of OB/GYN, NorthShore University HealthSystem, Clin Assoc Prof, University of Chicago, Pritzker School of Medicine

19. Pelvic Floor Unit, Hospital Universitario La Paz, Madrid

20. School of Women’s and Children’s Health, University of New South Wales, Sydney

21. The Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK

22. Service de Gastroenterologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Québec

Abstract

Abstract Background The evaluation of chronic pelvic and perineal pain (CPP) is often complex. The patient’s description of the pain often appears to be disproportionate to the limited findings on physical examination and/or complementary investigations. The concept of central sensitization may allow better understanding and management of patients with CPP. Objective The aim of this study was to elaborate a clinical evaluation tool designed to simply identify sensitization in pelvic pain. Methods A list of 63 items was submitted to 22 international CPP experts according to the Delphi method. Results Ten clinical criteria were adopted for the creation of a clinical evaluation tool: 1) pain influenced by bladder filling and/or urination, 2) pain influenced by rectal distension and/or defecation, 3) pain during sexual activity, 4) perineal and/or vulvar pain in response to normally nonpainful stimulation, 5) pelvic trigger points (e.g., in the piriformis, obturator internus, and/or levator ani muscles), 6) pain after urination, 7) pain after defecation, 8) pain after sexual activity, 9) variable (fluctuating) pain intensity and/or variable pain distribution, 10) migraine or tension headaches and/or fibromyalgia and/or chronic fatigue syndrome and/or post-traumatic stress disorder and/or restless legs syndrome and/or temporomandibular joint dysfunction and/or multiple chemical sensitivity. Conclusions  This process resulted in the elaboration of a clinical evaluation tool designed to identify and appropriately manage patients with CPP comprising a sensitization component.

Funder

NIH

Publisher

Oxford University Press (OUP)

Subject

Anesthesiology and Pain Medicine,Clinical Neurology,General Medicine

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