Disease Clearance as a New Outcome in Ulcerative Colitis: a Systematic Review and Expert Consensus-Reference-Cited by-同舟云学术

Disease Clearance as a New Outcome in Ulcerative Colitis: a Systematic Review and Expert Consensus

Published:2023-08-07 Issue: Volume: Page:
ISSN:1078-0998
Container-title:Inflammatory Bowel Diseases
language:en
Short-container-title:

Author:

D’Amico Ferdinando¹²^ORCID,Magro Fernando³,Siegmund Britta⁴^ORCID,Kobayashi Taku⁵,Kotze Paulo Gustavo⁶,Solitano Virginia²⁷,Caron Benedicte⁸⁹,Al Awadhi Sameer¹⁰,Hart Ailsa¹¹,Jairath Vipul⁷,Dignass Axel¹²,Peyrin-Biroulet Laurent⁸⁹,Danese Silvio¹^ORCID

Affiliation:

1. Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University , Milan , Italy

2. Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan , Italy

3. Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine of the University of Porto , Porto , Portugal

4. Medizinische Klinik m. S. Gastroenterologie, Infektiologie und Rheumatologie, Charité, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin , Berlin , Germany

5. Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital , Tokyo , Japan

6. Colorectal Surgery Unit, Hospital Universitário Cajuru, Pontifícia Universidade Católica do Paraná (PUCPR) , Curitiba , Brazil

7. Department of Medicine, Division of Gastroenterology, Western University , London, Ontario , Canada

8. University of Lorraine, CHRU-Nancy, Department of Gastroenterology , F-54000 Nancy , France

9. University of Lorraine, Inserm, NGERE , F-54000 Nancy , France

10. Digestive Diseases Unit, Rashid Hospital , Dubai 003206 , United Arab Emirates

11. St Mark’s Hospital , Harrow , Middlesex , UK

12. Department of Medicine I, Agaplesion Markus Hospital, Goethe-University , Frankfurt am Main , Germany

Abstract

AbstractThe concept of disease clearance has been proposed as a potential target in ulcerative colitis (UC). We conducted a systematic review to investigate the role of disease clearance, defined as a composite outcome including simultaneous clinical, endoscopic, and histologic remission of disease in the management of patients with UC. Based on the literature data, statements regarding disease clearance were developed and voted on by the members of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) according to a Delphi methodology. A definition of disease clearance was proposed to standardize its use in clinical practice and clinical trials and to provide practical recommendations for its implementation as a therapeutic target in UC.

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,Immunology and Allergy

Link

https://academic.oup.com/ibdjournal/advance-article-pdf/doi/10.1093/ibd/izad159/51048408/izad159.pdf

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