A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11

Author:

Siddiq Afshan12,Couch Fergus J.34,Chen Gary K.5,Lindström Sara6,Eccles Diana7,Millikan Robert C.8,Michailidou Kyriaki9,Stram Daniel O.5,Beckmann Lars10,Rhie Suhn Kyong5,Ambrosone Christine B.11,Aittomäki Kristiina12,Amiano Pilar13,Apicella Carmel14,Baglietto Laura1415,Bandera Elisa V.16,Beckmann Matthias W.17,Berg Christine D.18,Bernstein Leslie19,Blomqvist Carl20,Brauch Hiltrud21,Brinton Louise22,Bui Quang M.14,Buring Julie E.23,Buys Saundra S.24,Campa Daniele25,Carpenter Jane E.26,Chasman Daniel I.27,Chang-Claude Jenny28,Chen Constance6,Clavel-Chapelon Françoise29,Cox Angela30,Cross Simon S.31,Czene Kamila32,Deming Sandra L.33,Diasio Robert B.34,Diver W. Ryan35,Dunning Alison M.36,Durcan Lorraine7,Ekici Arif B.37,Fasching Peter A.1738,Feigelson Heather Spencer39,Fejerman Laura40,Figueroa Jonine D.22,Fletcher Olivia41,Flesch-Janys Dieter4243,Gaudet Mia M.35,Gerty Susan M.7,Rodriguez-Gil Jorge L.44,Giles Graham G.1415,van Gils Carla H.45,Godwin Andrew K.46,Graham Nikki7,Greco Dario47,Hall Per32,Hankinson Susan E.23,Hartmann Arndt48,Hein Rebecca2849,Heinz Judith4243,Hoover Robert N.22,Hopper John L.14,Hu Jennifer J.44,Huntsman Scott39,Ingles Sue A.5,Irwanto Astrid50,Isaacs Claudine51,Jacobs Kevin B.225253,John Esther M.5455,Justenhoven Christina21,Kaaks Rudolf28,Kolonel Laurence N.56,Coetzee Gerhard A.557,Lathrop Mark5859,Le Marchand Loic56,Lee Adam M.34,Lee I-Min23,Lesnick Timothy3,Lichtner Peter60,Liu Jianjun50,Lund Eiliv61,Makalic Enes14,Martin Nicholas G.62,McLean Catriona A.63,Meijers-Heijboer Hanne64,Meindl Alfons65,Miron Penelope66,Monroe Kristine R.5,Montgomery Grant W.62,Müller-Myhsok Bertram67,Nickels Stefan28,Nyante Sarah J.22,Olswold Curtis3,Overvad Kim68,Palli Domenico69,Park Daniel J.70,Palmer Julie R.71,Pathak Harsh46,Peto Julian72,Pharoah Paul36,Rahman Nazneen73,Rivadeneira Fernando74,Schmidt Daniel F.14,Schmutzler Rita K.75,Slager Susan3,Southey Melissa C.70,Stevens Kristen N.3,Sinn Hans-Peter76,Press Michael F.77,Ross Eric78,Riboli Elio1,Ridker Paul M.27,Schumacher Fredrick R.5,Severi Gianluca1415,dos Santos Silva Isabel72,Stone Jennifer14,Sund Malin79,Tapper William J.7,Thun Michael J.35,Travis Ruth C.80,Turnbull Clare73,Uitterlinden Andre G.74,Waisfisz Quinten64,Wang Xianshu4,Wang Zhaoming2252,Weaver JoEllen81,Schulz-Wendtland Rüdiger82,Wilkens Lynne R.56,Van Den Berg David5,Zheng Wei33,Ziegler Regina G.22,Ziv Elad40,Nevanlinna Heli47,Easton Douglas F.36,Hunter David J.683,Henderson Brian E.5,Chanock Stephen J.22,Garcia-Closas Montserrat84,Kraft Peter6,Haiman Christopher A.5,Vachon Celine M.3, , ,

Affiliation:

1. Department of Epidemiology and Biostatistics and

2. Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK,

3. Department of Health Sciences Research,

4. Department of Laboratory Medicine and Pathology and

5. Department of Preventive Medicine and

6. Program in Molecular and Genetic Epidemiology and

7. Faculty of Medicine, University of Southampton, Southampton, UK,

8. Department of Epidemiology, Gillings School of Global Public Health, and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA,

9. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and

10. Institute for Quality and Efficiency in Health Care, IQWiG, Cologne, Germany,

11. Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA,

12. Department of Clinical Genetics and

13. Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain,

14. Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health and

15. Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia,

16. The Cancer Institute of New Jersey, New Brunswick, NJ, USA,

17. Department of Gynecology and Obstetrics, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, University Breast Center Franconia, Erlangen, Germany,

18. Early Detection Research Group, Division of Cancer Prevention and

19. Division of Cancer Etiology, Department of Population Science, Beckman Research Institute, City of Hope, CA, USA,

20. Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland,

21. Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology and

22. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA,

23. Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA,

24. Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA,

25. Genomic Epidemiology Group and

26. Australian Breast Cancer Tissue Bank, Westmead Millennium Institute and

27. Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA,

28. Division of Cancer Epidemiology, German Cancer Research Center and

29. INSERM UMR 1018, Team 9: Nutrition, Hormones et Santé desfemmes, Centre de Recherche en Epidémiologie et Santé des Populations, Hôpital Paul Brousse, Villejuif, France,

30. Institute for Cancer Studies, Department of Oncology and

31. Academic Unit of Pathology, Department of Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK,

32. Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden,

33. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center Vanderbilt University School of Medicine, Nashville, TN, USA,

34. Department of Pharmacology, Mayo Clinic, Rochester, MN, USA,

35. Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA,

36. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK,

37. Friedrich-Alexander University Erlangen-Nuremberg, Institute of Human Genetics, Erlangen, Germany,

38. David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, USA,

39. Institute for Health Research, Kaiser Permanente, Denver, CO, USA,

40. Division of General Internal Medicine, Department of Medicine, Institute for Human Genetics and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA,

41. Institute of Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK,

42. Department of Cancer Epidemiology/Clinical Cancer Registry, University Cancer Center Hamburg (UCCH) , Hamburg, Germany,

43. Department of Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany,

44. Sylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health, University of Miami Miller School of Medicine, Miami, FL, USA,

45. Julius Center, University Medical Center, Utrecht, The Netherlands,

46. Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS, USA,

47. Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland and

48. Institute of Pathology and

49. PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy and

50. Human Genetics Division, Genome Institute of Singapore, Singapore, Singapore,

51. Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA,

52. Core Genotyping Facility, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD, USA,

53. Bioinformed Consulting Services, Gaithersburg, MD, USA,

54. Cancer Prevention Institute of California, Fremont, CA, USA,

55. Stanford University School of Medicine, Stanford Cancer Institute, Stanford, CA, USA,

56. Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA,

57. Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA,

58. Centre National de Genotypage, Evry, France,

59. Fondation Jean Dausset, CEPH, Paris, France,

60. Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany,

61. Institute of Community Medicine, University of Tromsø, Tromsø, Norway,

62. QIMR GWAS Collective, Queensland Institute of Medical Research, Brisbane, Australia,

63. The Alfred Hospital, Melbourne, Australia,

64. Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands,

65. Clinic of Gynaecology and Obstetrics, Division for Gynaecological Tumor-Genetics, Technische Universität München, München, Germany,

66. Dana Farber Cancer Institute, Boston, MA, USA,

67. Max Planck Institute of Psychiatry, Munich, Germany,

68. Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark,

69. Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, ISPO, Florence, Italy,

70. Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia,

71. Slone Epidemiology Center at Boston University, Boston, MA, USA,

72. Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK,

73. Section of Cancer Genetics and

74. Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands,

75. Division of Molecular Gynaeco-Oncology, Department of Obstetrics and Gynaecology, University of Cologne, Cologne, Germany,

76. Department of Pathology, University Hospital Heidelberg, Heidelberg, Germany,

77. Department of Pathology, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA,

78. Department of Biostatistics and

79. Department of Surgery, Umeå University, Umea, Sweden and

80. Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK

81. Biosample Repository, Fox Chase Cancer Center, Philadelphia, PA, USA,

82. Institute of Diagnostic Radiology, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany,

83. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA,

84. Section of Epidemiology and Genetics, Institute of Cancer Research, Sutton, UK,

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

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