Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium

Author:

Broeks Annegien1,Schmidt Marjanka K.12,Sherman Mark E.3,Couch Fergus J.45,Hopper John L.6,Dite Gillian S.6,Apicella Carmel6,Smith Letitia D.7,Hammet Fleur7,Southey Melissa C.7,Van ’t Veer Laura J.18,de Groot Renate8,Smit Vincent T.H.B.M.9,Fasching Peter A.10,Beckmann Matthias W.11,Jud Sebastian11,Ekici Arif B.12,Hartmann Arndt13,Hein Alexander11,Schulz-Wendtland Ruediger14,Burwinkel Barbara1516,Marme Frederik15,Schneeweiss Andreas15,Sinn Hans-Peter17,Sohn Christof15,Tchatchou Sandrine1516,Bojesen Stig E.1819,Nordestgaard Børge G.1819,Flyger Henrik1819,Ørsted David D.1819,Kaur-Knudsen Diljit1819,Milne Roger L.20,Pérez Jose I. Arias21,Zamora Pilar22,Rodríguez Primitiva Menéndez23,Benítez Javier2425,Brauch Hiltrud2627,Justenhoven Christina2627,Ko Yon-Dschun28,Hamann Ute29,Fischer Hans-Peter30,Brüning Thomas31,Pesch Beate31,Chang-Claude Jenny32,Wang-Gohrke Shan33,Bremer Michael34,Karstens Johann H.34,Hillemanns Peter35,Dörk Thilo35,Nevanlinna Heli A.36,Heikkinen Tuomas36,Heikkilä Päivi37,Blomqvist Carl38,Aittomäki Kristiina39,Aaltonen Kirsimari3638,Lindblom Annika40,Margolin Sara41,Mannermaa Arto4243,Kosma Veli-Matti4243,Kauppinen Jaana M.4243,Kataja Vesa44,Auvinen Päivi45,Eskelinen Matti46,Soini Ylermi4243,Chenevix-Trench Georgia47,Spurdle Amanda B.47,Beesley Jonathan47,Chen Xiaoqing47,Holland Helene47,Lambrechts Diether48,Claes Bart48,Vandorpe Thijs49,Neven Patrick49,Wildiers Hans49,Flesch-Janys Dieter50,Hein Rebecca32,Löning Thomas51,Kosel Matthew45,Fredericksen Zachary S.45,Wang Xianshu45,Giles Graham G.52,Baglietto Laura53,Severi Gianluca52,McLean Catriona53,Haiman Christopher A.54,Henderson Brian E.54,Le Marchand Loic55,Kolonel Laurence N.55,Grenaker Alnæs Grethe56,Kristensen Vessela5657,Børresen-Dale Anne-Lise5657,Hunter David J.5859,Hankinson Susan E.5859,Andrulis Irene L.606162,Marie Mulligan Anna6263,O'Malley Frances P.6264,Devilee Peter65,Huijts Petra E.A.66,Tollenaar Rob A.E.M.67,Van Asperen Christi J.66,Seynaeve Caroline S.68,Chanock Stephen J.69,Lissowska Jolanta70,Brinton Louise71,Peplonska Beata72,Figueroa Jonine3,Yang Xiaohong R.3,Hooning Maartje J.73,Hollestelle Antoinette73,Oldenburg Rogier A.74,Jager Agnes73,Kriege Mieke73,Ozturk Bahar73,van Leenders Geert J.L.H.75,Hall Per76,Czene Kamila76,Humphreys Keith76,Liu Jianjun77,Cox Angela78,Connley Daniel78,Cramp Helen E.78,Cross Simon S.79,Balasubramanian Sabapathy P.80,Reed Malcolm W.R.80,Dunning Alison M.45,Easton Douglas F.81,Humphreys Manjeet K.81,Caldas Carlos45,Blows Fiona45,Driver Kristy45,Provenzano Elena45,Lubinski Jan82,Jakubowska Anna82,Huzarski Tomasz82,Byrski Tomasz82,Cybulski Cezary82,Gorski Bohdan82,Gronwald Jacek82,Brennan Paul83,Sangrajrang Suleeporn84,Gaborieau Valerie83,Shen Chen-Yang8586,Hsiung Chia-Ni85,Yu Jyh-Cherng87,Chen Shou-Tung88,Hsu Giu-Cheng89,Hou Ming-Feng90,Huang Chiun-Sheng91,Anton-Culver Hoda92,Ziogas Argyrios92,Pharoah Paul D.P.4581,Garcia-Closas Montserrat34581, , ,

Affiliation:

1. Department of Experimental Therapy,

2. Department of Epidemiology and

3. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA,

4. Department of Laboratory Medicine and Pathology and

5. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA,

6. Centre for Molecular, Environmental, Genetic and Analytic Epidemiology and

7. Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia,

8. Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands,

9. Department of Pathology, Leiden University Medical Centre, Leiden, the Netherlands,

10. Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA,

11. Department of Gynecology and Obstetrics,

12. Institute of Human Genetics, Friedrich Alexander University Erlangen, Nürnberg, Germany,

13. Institute of Pathology,

14. Institute of Radiology, University Breast Center, University Hospital Erlangen, Erlangen, Germany,

15. Department of Gynecology and Obstetrics and

16. Molecular Epidemiology and

17. Department of Pathology, University Hospital Heidelberg, Heidelberg, Germany,

18. Department of Clinical Biochemistry and

19. Department of Breast Surgery, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark,

20. Genetic & Molecular Epidemiology Group and

21. Servicio Cirugía General and

22. Servicio de Oncología Médica, Hospital La Paz, Madrid, Spain,

23. Servicio de Anatomía Patológica, Hospital Monte Naranco, Oviedo, Spain,

24. Human Cancer Genetic Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain,

25. CIBERER, Madrid, Spain,

26. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany,

27. University Tübingen, Tübingen, Germany,

28. Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany,

29. Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany,

30. Institute of Pathology, Medical Faculty of the University of Bonn, Bonn, Germany,

31. Institute of Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany,

32. Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany,

33. Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany,

34. Hannover Medical School, Clinics of Radiation Oncology, Hannover, Germany,

35. Clinics of Obstetrics and Gynaecology, Hannover, Germany,

36. Department of Obstetrics and Gynecology,

37. Department of Pathology and

38. Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland,

39. Department of Clinical Genetics,

40. Department of Molecular Medicine and Surgery,

41. Department of Oncology and Pathology and

42. Department of Pathology, Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland,

43. Biocenter Kuopio, Kuopio, Finland,

44. Department of Oncology, Vaasa Central Hospital, Vaasa, Finland,

45. Department of Oncology and

46. Department of Surgery, Kuopio University Hospital, Kuopio, Finland,

47. Queensland Institute of Medical Research, Brisbane, Australia,

48. Vesalius Research Center, KU Leuven and VIB, Leuven, Belgium,

49. Multidisciplinary Breast Center, University Hospitals Leuven, Belgium,

50. Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Germany,

51. Albertinen Pathology Department, Hamburg, Germany,

52. Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia,

53. Department of Anatomical Pathology, Alfred Hospital, Melbourne, Australia,

54. Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA,

55. Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA,

56. Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Montebello 0310, Oslo, Norway,

57. Faculty of Medicine (Faculty Division Ahus), UiO, Norway,

58. Channing Laboratory, Department of Medicine, Brigham and Womens Hospital and Harvard Medical school, Boston, MA, USA,

59. Department of Epidemiology, Harvard school of public health, Boston, MA, USA,

60. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario Cancer Genetics Network, Cancer Care Ontario, Ontario, Canada,

61. Department of Molecular Genetics and

62. Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada,

63. Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael's Hospital, Toronto, Ontario, Canada,

64. The Department of Laboratory Medicine and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada

65. Department Human Genetics & Department of Pathology,

66. Clinical Genetics and

67. Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands,

68. Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands,

69. Advanced Technology Center, National Cancer Institute, Gaithersburg, MD 20892-4605, USA,

70. Department of Cancer Epidemiology and Prevention, Cancer Center and M. Sklodowska-Curie Institute of Oncology, 02-781 Warsaw, Poland,

71. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852-7234, USA,

72. Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland,

73. Department of Medical Oncology,

74. Department of Clinical Genetics and

75. Department of Pathology, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands,

76. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden,

77. Human Genetics Laboratory, Genome Institute of Singapore, Singapore,

78. Department of Oncology, Institute for Cancer Studies,

79. Academic Unit of Pathology, Department of Oncology and

80. Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield Medical School, Sheffield, UK,

81. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK,

82. Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland,

83. International agency for Research on Cancer, Lyon, France,

84. National Cancer Institute, Bangkok, Thailand,

85. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan,

86. Graduate Institute of Environmental Science, China Medical University, Taichung, Taiwan,

87. Department of Surgery and

88. Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan,

89. Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan,

90. Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan,

91. Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan,

92. Department of Epidemiology, University of California at Irvine, Irvine, CA 92697, USA

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

Reference39 articles.

1. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications;Sorlie;Proc. Natl Acad. Sci. USA,2001

2. Molecular portraits of human breast tumours;Perou;Nature,2000

3. Gene expression pathway analysis to predict response to neoadjuvant docetaxel and capecitabine for breast cancer;Korde;Breast Cancer Res. Treat.,2010

4. Concordant gene expression signatures predict clinical outcomes of cancer patients undergoing systemic therapy;Williams;Cancer Res.,2009

5. Etiology of hormone receptor-defined breast cancer: a systematic review of the literature;Althuis;Cancer Epidemiol. Biomarkers Prev.,2004

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