Long-Term Habitual Vigorous Physical Activity Is Associated With Lower Visit-to-Visit Systolic Blood Pressure Variability: Insights From the SPRINT Trial

Abstract

Abstract Background Our work aimed to investigate the association between vigorous physical activity and visit-to-visit systolic blood pressure variability (BPV). Methods We conducted a post hoc analysis of SPRINT (Systolic Blood Pressure Intervention Trial), a well-characterized cohort of participants randomized to intensive (<120 mm Hg) or standard (<140 mm Hg) systolic blood pressure targets. We assessed whether patients with hypertension who habitually engage in vigorous physical activity would have lower visit-to-visit systolic BPV compared with those who do not engage in vigorous physical activity. Visit-to-visit systolic BPV was calculated by SD, average real variability (ARV), and SD independent of the mean (SDIM) using measurements taken during the 1-, 2-, 3-, 6-, 9-, and 12-month study visits. A medical history questionnaire assessed vigorous physical activity, which was divided into 3 categories according to the frequency of vigorous physical activity. Results A total of 7,571 participants were eligible for analysis (34.8% female, mean age 67.9 ± 9.3 years). During a follow-up of 1-year, vigorous physical activity could significantly reduce SD, ARV, and SDIM across increasing frequency of vigorous physical activity. There were negative linear trends between frequency of vigorous physical activity and visit-to-visit systolic BPV. Conclusions Long-term engagement in vigorous physical activity was associated with lower visit-to-visit systolic BPV. Clinical trials registration SPRINT (Systolic Blood Pressure Intervention Trial); Trial Number: NCT01206062, https://clinicaltrials.gov/ct2/show/NCT01206062.