Calprotectin: two sides of the same coin-Reference-Cited by-同舟云学术

Calprotectin: two sides of the same coin

Published:2023-08-21 Issue:1 Volume:63 Page:26-33
ISSN:1462-0324
Container-title:Rheumatology
language:en
Short-container-title:

Author:

Carnazzo Valeria¹,Redi Serena¹²,Basile Valerio³,Natali Patrizia⁴,Gulli Francesca⁵,Equitani Francesco⁶,Marino Mariapaola⁷⁸^ORCID,Basile Umberto¹^ORCID

Affiliation:

1. Department of Clinical Pathology, Santa Maria Goretti Hospital, AUSL Latina , Latina, Italy

2. Facoltà di medicina e Chirurgia, Department of Clinical Pathology, Università “La Sapienza” , Rome, Italy

3. Clinical Pathology Unit and Cancer Biobank, Department of Research and Advanced Technologies, IRCCS Regina Elena National Cancer Institute , Rome, Italy

4. Department of Laboratory Medicine and Pathology, Azienda Ospedaliero Universitaria e Azienda Unità Sanitaria Locale di Modena , Modena, Italy

5. Clinical Biochemistry Laboratory, IRCCS “Bambino Gesù” Children’s Hospital , Rome, Italy

6. Department of Transfusion Medicine and Immuno-Hematology, Santa Maria Goretti Hospital, AUSL Latina , Latina, Italy

7. Dipartimento di Medicina e Chirurgia Traslazionale, Sezione di Patologia Generale, Università Cattolica del Sacro Cuore , Rome, Italy

8. Fondazione Policlinico Universitario “A. Gemelli” IRCCS , Rome, Italy

Abstract

Abstract Calprotectin (CLP) is a calcium-binding protein produced by neutrophils and monocytes in the course of inflammation. Today, the role of faecal CLP in chronic IBD is well known, but in recent years attention has shifted towards circulating CLP. In fact, this molecule can be measured in different biological fluids: blood, saliva and urine, using different analytic methods that are described in this review. Furthermore, different data confirm the relevant role of serum CLP in autoimmune diseases. In this review we will highlight the correlation between high levels of circulating CLP and specific autoantibodies of major autoimmune pathologies paving the way to the employment of CLP measurement as useful biomarker for monitoring outcome in different pathologies.

Funder

Università Cattolica del Sacro Cuore Fondazione Policlinico Universitario

Publisher

Oxford University Press (OUP)

Subject

Pharmacology (medical),Rheumatology

Link

https://academic.oup.com/rheumatology/advance-article-pdf/doi/10.1093/rheumatology/kead405/54520476/kead405.pdf

Reference49 articles.

1. Calprotectin: from biomarker to biological function;Jukic;Gut,2021

2. The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins;Korndörfer;J Mol Biol,2007

3. Calprotectin in rheumatic diseases;Ometto;Exp Biol Med,2017

4. A simple method for assessing intestinal inflammation in Crohn’s disease;Tibble;Gut,2000

5. The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer;Ehrchen;J Leukoc Biol,2009

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Spatiotemporal Control of Immune Responses with Nucleic Acid Cocktail Vaccine;Advanced Therapeutics;2024-09-06

2. Serum Calprotectin in the Evaluation of Gastrointestinal Diseases: An Ace up Your Sleeve?;Medicina;2024-05-05

3. The aryl hydrocarbon receptor agonist ITE reduces inflammation and urinary dysfunction in a mouse model of autoimmune prostatitis;American Journal of Clinical and Experimental Urology;2024