Serum Calprotectin in the Evaluation of Gastrointestinal Diseases: An Ace up Your Sleeve?-Reference-Cited by-同舟云学术

Serum Calprotectin in the Evaluation of Gastrointestinal Diseases: An Ace up Your Sleeve?

Published:2024-05-05 Issue:5 Volume:60 Page:762
ISSN:1648-9144
Container-title:Medicina
language:en
Short-container-title:Medicina

Author:

Saviano Angela¹²,Migneco Alessio¹^ORCID,Brigida Mattia³,Petruzziello Carmine⁴^ORCID,Zanza Christian⁵,Savioli Gabriele⁶^ORCID,Franceschi Francesco¹²,Ojetti Veronica²⁴^ORCID

Affiliation:

1. Emergency Department, Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy

2. Department of Medicine, Catholic University of the Sacred Heart, 00168 Rome, Italy

3. Gastroenterology Unit, Policlinico Universitario Tor Vergata, 00133 Rome, Italy

4. Department of Emergency Medicine, Ospedale San Carlo di Nancy, GVM Care and Research, 00165 Rome, Italy

5. Geriatric Medicine Residency Program, University of Rome “Tor Vergata”, 00133 Rome, Italy

6. Emergency Medicine and Surgery, IRCCS Fondazione Policlinico San Matteo, 27100 Pavia, Italy

Abstract

Background: Calprotectin (CP) is a calcium- and zinc-binding protein that plays a key role in innate immunity and in the recruitment of inflammatory cells. CP can be detected both in serum and in fecal samples. Serum CP (sCP) is more specific for autoimmune diseases, while fecal CP (fCP) has been well investigated for gastrointestinal diseases. Few studies have shown the clinical effectiveness of sCP as an acute-phase biomarker for gastrointestinal diseases. Aim: The aim of this narrative review is to discuss the role of sCP as a useful alternative biomarker of the acute-phase activity of gastrointestinal diseases and as a possible tool for screening and monitoring these diseases. Material and Methods: We searched original articles, abstracts, reviews, case reports, and clinical trials on PubMed®, Up-to-Date®, and Medscape® in the last ten years. Conclusion: We found that sCP could represent a useful biomarker in the evaluation of the inflammatory stage in patients with immune-mediated gastrointestinal diseases, but more studies are needed to promote its routine use in clinical practice as a diagnostic and prognostic biomarker as a replacement for fCP.

Publisher

MDPI AG

Link

https://www.mdpi.com/1648-9144/60/5/762/pdf

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