Membrane scaffolds for matrix-induced autologous chondrocyte implantation in the knee: a systematic review

Abstract

Abstract Introduction Chondral defects of the knee are common and their management is challenging. Source of data Current scientific literature published in PubMed, Google scholar, Embase and Scopus. Areas of agreement Membrane-induced autologous chondrocyte implantation (mACI) has been used to manage chondral defects of the knee. Areas of controversy Hyaluronic acid membrane provides better outcomes than a collagenic membrane for mACI in the knee at midterm follow-up is controversial. Growing points To investigate whether hyaluronic acid membrane may provide comparable clinical outcomes than collagenic membranes for mACI in focal defects of the knee. Areas timely for developing research Hyaluronic acid membrane yields a lower rate of failures and revision surgeries for mACI in the management of focal articular cartilage defects of the knee compared with collagenic scaffolds at midterm follow-up. No difference was found in patient reported outcome measures (PROMs). Further comparative studies are required to validate these results in a clinical setting.