Enabling a learning healthcare system with automated computer protocols that produce replicable and personalized clinician actions

Author:

Morris Alan H12ORCID,Stagg Brian3,Lanspa Michael4,Orme James124,Clemmer Terry P1245,Weaver Lindell K124,Thomas Frank65,Grissom Colin K124,Hirshberg Ellie4,East Thomas D7,Wallace Carrie Jane35,Young Michael P8,Sittig Dean F9ORCID,Pesenti Antonio10,Bombino Michela11,Beck Eduardo12,Sward Katherine A213,Weir Charlene213ORCID,Phansalkar Shobha S14,Bernard Gordon R15,Taylor Thompson B16,Brower Roy17,Truwit Jonathon D18,Steingrub Jay19,Duncan Hite R20,Willson Douglas F21,Zimmerman Jerry J22,Nadkarni Vinay M2324,Randolph Adrienne25,Curley Martha A. Q2426,Newth Christopher J. L27,Lacroix Jacques28,Agus Michael S. D25,Lee Kang H29,deBoisblanc Bennett P30,Scott Evans R25,Sorenson Dean K25,Wong Anthony31,Boland Michael V32,Grainger David W33,Dere Willard H33,Crandall Alan S3,Facelli Julio C234,Huff Stanley M2,Haug Peter J2,Pielmeier Ulrike35,Rees Stephen E35,Karbing Dan S35,Andreassen Steen35,Fan Eddy36,Goldring Roberta M37,Berger Kenneth I37,Oppenheimer Beno W37,Wesley Ely E153839,Gajic Ognjen40,Pickering Brian41,Schoenfeld David A42,Tocino Irena43,Gonnering Russell S44,Pronovost Peter J45,Savitz Lucy A46,Dreyfuss Didier47,Slutsky Arthur S48,Crapo James D49,Angus Derek50,Pinsky Michael R50,James Brent51,Berwick Donald52

Affiliation:

1. Pulmonary, Critical Care, and Sleep Division, Department of Internal Medicine

2. Department of Biomedical Informatics

3. Department of Ophthalmology and Visual Sciences and John Moran Eye Center

4. Pulmonary, Critical Care, and Sleep Division, Department of Internal Medicine, Intermountain Healthcare, Salt Lake City, Utah, USA

5. Emeritus

6. Department of Value Engineering, University of Utah Hospitals and Clinics, Salt Lake City, Utah, USA

7. SYNCRONYS, and University of New Mexico Health Sciences Library & Informatics, Albuquerque, New Mexico, USA

8. Critical Care Division, Renown Medical Center, School of Medicine, University of Nevada, Reno, Nevada, USA

9. School of Biomedical Informatics, University of Texas Health Science Center, Houston, Texas, USA

10. Dipartimento di Anestesia, Rianimazione ed Emergenza-Urgenza, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

11. Department of Emergency and Intensive Care Medicine, ASST-Monza San Gerardo Hospital, Milan, Italy

12. Ospedale di Desio—ASST Monza, UOC Anestesia e Rianimazione, Milan, Italy

13. School of Nursing

14. Division of General Medicine and Primary Care, Brigham and Women's Hospital

15. Pulmonary, Critical Care, and Allergy Division, Department of Internal Medicine

16. Pulmonary, Critical Care, and Sleep Division , Department of Internal Medicine

17. Pulmonary, Critical Care, and Sleep Division, Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

18. Pulmonary, Critical Care, and Sleep Division, Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

19. Pulmonary, Critical Care, and Sleep Division, Department of Internal Medicine, University of Massachusetts Medical School-Baystate, Springfield, Massachusetts, USA

20. Pulmonary, Critical Care, and Sleep Division, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA

21. Division of Pediatric Critical Care, Department of Pediatrics, Virginia Commonwealth University, Richmond, Virginia, USA

22. Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA

23. Department of Anesthesia and Critical Care Medicine

24. Department of Pediatrics, Perelman School of Medicine

25. Department of Pediatrics

26. School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA

27. Department of Pediatrics, University of Southern California, Los Angeles, California, USA

28. Division of Pediatric Critical Care Medicine, Department of Pediatrics, CHU Sainte-Justine and Université de Montréal, Montréal, Canada

29. Asian American Liver Centre, Gleneagles Hospital, Singapore, Singapore

30. Section of Pulmonary/Critical Care & Allergy/Immunology, Louisiana State University School of Medicine, New Orleans, Louisiana, USA

31. Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA

32. Massachusetts Eye and Ear

33. Department of Biomedical Engineering and Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah

34. Center for Clinical and Translational Science, School of Medicine

35. Department of Health Science and Technology, Aalborg University, Aalborg, Denmark

36. Institute of Health Policy, Management and Evaluation

37. Pulmonary, Critical Care, and Sleep Division, NYU School of Medicine, New York, New York, USA

38. Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center

39. Tennessee Valley Veterans Affairs Geriatric Research Education Clinical Center (GRECC), Nashville, Tennessee, USA

40. Pulmonary , Critical Care, and Sleep Division, Department of Internal Medicine

41. Department of Anesthesiology and Perioperative Medicine, Mayo Clinic School of Medicine, Rochester, Minnesota, USA

42. Department of Biostatistics, T.H. Chan School of Public Health, Harvard Medical School, Boston, Massachusetts, USA

43. Department of Radiology, Yale University School of Medicine, New Haven, Connecticut, USA

44. Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

45. Critical Care, Department of Anesthesia, Chief Clinical Transformation Officer, University Hospitals, Highland Hills, Case Western Reserve University, Cleveland, OH, USA

46. Kaiser Permanente Northwest Center for Health Research, Portland, OR, USA

47. Assistance Publique – Hôpitaux de Paris, Université de Paris, INSERM unit UMR S_1155 (Common and Rare Kidney Diseases), Sorbonne Université, Paris, France

48. Keenan Research Center, Li Ka Shing Knowledge Institute / ST. Michaels' Hospital and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada

49. Department of Internal Medicine, National Jewish Health, Denver, Colorado, USA

50. Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

51. Clinical Excellence Research Center (CERC), Department of Medicine, Stanford University School of Medicine, Palo Alto, California, USA

52. Institute for Healthcare Improvement, Boston, Massachusetts, USA

Abstract

Abstract Clinical decision-making is based on knowledge, expertise, and authority, with clinicians approving almost every intervention—the starting point for delivery of “All the right care, but only the right care,” an unachieved healthcare quality improvement goal. Unaided clinicians suffer from human cognitive limitations and biases when decisions are based only on their training, expertise, and experience. Electronic health records (EHRs) could improve healthcare with robust decision-support tools that reduce unwarranted variation of clinician decisions and actions. Current EHRs, focused on results review, documentation, and accounting, are awkward, time-consuming, and contribute to clinician stress and burnout. Decision-support tools could reduce clinician burden and enable replicable clinician decisions and actions that personalize patient care. Most current clinical decision-support tools or aids lack detail and neither reduce burden nor enable replicable actions. Clinicians must provide subjective interpretation and missing logic, thus introducing personal biases and mindless, unwarranted, variation from evidence-based practice. Replicability occurs when different clinicians, with the same patient information and context, come to the same decision and action. We propose a feasible subset of therapeutic decision-support tools based on credible clinical outcome evidence: computer protocols leading to replicable clinician actions (eActions). eActions enable different clinicians to make consistent decisions and actions when faced with the same patient input data. eActions embrace good everyday decision-making informed by evidence, experience, EHR data, and individual patient status. eActions can reduce unwarranted variation, increase quality of clinical care and research, reduce EHR noise, and could enable a learning healthcare system.

Funder

NIH

Deseret Foundation, and Intermountain Healthcare, Inc

Publisher

Oxford University Press (OUP)

Subject

Health Informatics

Reference207 articles.

1. Era 3 for medicine and health care;Berwick;JAMA,2016

2. Clinician decisions and computers;Diamond;J Am Coll Cardiol,1987

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