Increasing the throughput of label-free cell assays to study the activation of G-protein-coupled receptors by using a serial agonist exposure protocol-Reference-Cited by-同舟云学术

Increasing the throughput of label-free cell assays to study the activation of G-protein-coupled receptors by using a serial agonist exposure protocol

Published:2019-03-01 Issue:3 Volume:11 Page:99-108
ISSN:1757-9708
Container-title:Integrative Biology
language:en
Short-container-title:

Author:

Stolwijk J A¹,Skiba M¹,Kade C¹,Bernhardt G²,Buschauer A²,Hübner H³,Gmeiner P³,Wegener J¹⁴

Affiliation:

1. Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, Regensburg, Germany

2. Institute of Pharmacy, University of Regensburg, Regensburg, Germany

3. Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg FAU, Erlangen, Germany

4. Fraunhofer Research Institution for Microsystems and Solid State Technologies EMFT, Munich, Germany

Funder

DFG Research Training Group

Publisher

Oxford University Press (OUP)

Subject

Biochemistry,Biophysics

Link

http://academic.oup.com/ib/advance-article-pdf/doi/10.1093/intbio/zyz010/28604711/zyz010.pdf

Reference39 articles.

1. The structure and function of G-protein-coupled receptors;Rosenbaum;Nature,2009

2. Cellular assays as portals to seven-transmembrane receptor-based drug discovery;Kenakin;Nat Rev Drug Discov,2009

3. Label-free drug discovery;Fang;Front Pharmacol,2014

4. Tools for GPCR drug discovery;Zhang;Acta Pharmacol Sin,2012

5. Label-free whole-cell assays: expanding the scope of GPCR screening;Scott;Drug Discov Today,2010

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