Cellular assays as portals to seven-transmembrane receptor-based drug discovery
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd2838.pdf
Reference99 articles.
1. Black, J. W., Duncan, W. A. & Shanks, R. G. Comparison of some properties of pronethalol and propranolol. Br. J. Pharmacol. Chemo. 25, 577–591 (1965).
2. Azzi, M. et al. β-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G-protein-coupled receptors. Proc. Natl Acad. Sci. USA 100, 11406–11411 (2003).
3. Costa, T. & Herz, A. Antagonists with negative intrinsic activity at δ-opioid receptors coupled to GTP-binding proteins. Proc. Natl Acad. Sci. 86, 7321–7325 (1989).
4. Kenakin, T. P. Efficacy as a vector: the prevalence and paucity of inverse agonism. Mol. Pharmacol. 65, 2–11 (2004).
5. Metra, M., Cas, L. D., di Lenarda, A. & Poole-Wilson, P. Beta-blockers in hear failure: Are pharmacological differences clinically important? Heart Fail. Rev. 9, 123–130 (2005).
Cited by 150 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Know your molecule: pharmacological characterization of drug candidates to enhance efficacy and reduce late-stage attrition;Nature Reviews Drug Discovery;2024-06-18
2. Probing Activation and Conformational Dynamics of the Vesicle-Reconstituted β2 Adrenergic Receptor at the Single-Molecule Level;The Journal of Physical Chemistry B;2024-02-23
3. The science of finding drug molecules I: applying pharmacology to discovery/target identification and validation;Pharmacology in Drug Discovery and Development;2024
4. Comparative Saturation Binding Analysis of 64Cu-Labeled Somatostatin Analogues Using Cell Homogenates and Intact Cells;ACS Omega;2023-06-22
5. Application of Machine Learning Technology in the Prediction of ADME- Related Pharmacokinetic Parameters;Current Medicinal Chemistry;2023-05
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3