Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates

Author:

Nyberg Lars1234,Andersson Micael23,Lundquist Anders35,Baaré William F C67,Bartrés-Faz David89,Bertram Lars1011,Boraxbekk Carl-Johan13671213,Brandmaier Andreas M141516,Demnitz Naiara67,Drevon Christian A171819,Duezel Sandra14,Ebmeier Klaus P20,Ghisletta Paolo212223,Henson Richard24,Jensen Daria E A202526,Kievit Rogier A27,Knights Ethan24,Kühn Simone2829,Lindenberger Ulman1416,Plachti Anna67,Pudas Sara23,Roe James M10,Madsen Kathrine Skak673031,Solé-Padullés Cristina89,Sommerer Yasmine11,Suri Sana2027,Zsoldos Enikő2027ORCID,Fjell Anders M1032,Walhovd Kristine B1032ORCID

Affiliation:

1. Department of Radiation Sciences (Radiology), Umeå University , 901 87 Umeå , Sweden

2. Department of Integrative Medical Biology, Umeå University , 901 87 Umeå , Sweden

3. Umeå Center for Functional Brain Imaging, Umeå University , 901 87 Umeå , Sweden

4. Center for Lifespan Changes in Brain and Cognition, University of Oslo , Department of Psychology, University of Oslo, 0373 Oslo , Norway

5. Department of Statistics, USBE, Umeå University , Umeå S-90187 , Sweden

6. Danish Research Centre for Magnetic Resonance , Centre for Functional and Diagnostic Imaging and Research, , 2650 Copenhagen , Denmark

7. Copenhagen University Hospital - Amager and Hvidovre , Centre for Functional and Diagnostic Imaging and Research, , 2650 Copenhagen , Denmark

8. Department of Medicine , Faculty of Medicine and Health Sciences, , 08036 Barcelona , Spain

9. Institut de Neurociències, Universitat de Barcelona, and Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS) , Faculty of Medicine and Health Sciences, , 08036 Barcelona , Spain

10. Center for Lifespan Changes in Brain and Cognition, University of Oslo, Department of Psychology, University of Oslo , 0373 Oslo , Norway

11. Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck , 23562 Lübeck , Germany

12. Faculty of Medical and Health Sciences, Institute for Clinical Medicine, University of Copenhagen , 2400 Copenhagen , Denmark

13. Department of Neurology, Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital - Bispebjerg and Frederiksberg , 2400 Copenhagen , Denmark

14. Center for Lifespan Psychology, Max Planck Institute for Human Development , 14195 Berlin , Germany

15. MSB Medical School Berlin , 14197 Berlin , Germany

16. Max Plank UCL Centre for Computational Psychiatry and Ageing Research , 14195 Berlin, Germany, and London , UK

17. Vitas AS , Science Park, 0349 Oslo , Norway

18. Department of Nutrition , Faculty of Medicine, , 0317 Oslo Norway

19. Institute of Basic Medical Sciences, University of Oslo , Faculty of Medicine, , 0317 Oslo Norway

20. Department of Psychiatry, University of Oxford , OX3 7JX Oxford , UK

21. Faculty of Psychology and Educational Sciences, University of Geneva , 1204 Geneva , Switzerland

22. UniDistance Suisse , 3900 Brig , Switzerland

23. Swiss National Centre of Competence in Research LIVES, University of Geneva , 1204 Geneva , Switzerland

24. Medical Research Council Cognition and Brain Sciences Unit, Department of Psychiatry, University of Cambridge , Cambridge CB2 7EF, England

25. Wellcome Centre for Integrative Neuroimaging , Oxford Centre for Human Brain Activity, , OX3 9DU Oxford , UK

26. University of Oxford , Oxford Centre for Human Brain Activity, , OX3 9DU Oxford , UK

27. Cognitive Neuroscience Department, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center , 6525 GD Nijmegen , The Netherlands

28. Lise Meitner Group for Environmental Neuroscience , Max Planck Institute for Human Development & Clinic for Psychiatry and Psychotherapy, , 20246 Hamburg, Germany

29. University Medical Center Hamburg-Eppendorf , Max Planck Institute for Human Development & Clinic for Psychiatry and Psychotherapy, , 20246 Hamburg, Germany

30. Radiography , Department of Technology, , 2200 Copenhagen N , Denmark

31. University College Copenhagen , Department of Technology, , 2200 Copenhagen N , Denmark

32. Center for Computational Radiology and Artificial Intelligence, Oslo University Hospital , 0373 Oslo , Norway

Abstract

Abstract It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.

Funder

Knut och Alice Wallenbergs Stiftelse

EU Horizon 2020

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

Reference44 articles.

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