Hippocampal Asymmetry of Regional Development and Structural Covariance in Preterm Neonates

Author:

Ge Xinting123,Zheng Yuanjie1,Qiao Yuchuan2,Pan Ningning1,Simon Julia Pia2,Lee Mitchell2,Jiang Wenjuan4,Kim Hosung2ORCID,Shi Yonggang2,Liu Mengting2

Affiliation:

1. School of Information Science and Engineering, Shandong Normal University, 250014 Jinan, China

2. Department of Neurology, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA

3. School of Medical Imaging, Xuzhou Medical University, 221004 Xuzhou, China

4. College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA

Abstract

Abstract Premature birth is associated with a high prevalence of neurodevelopmental impairments in surviving infants. The hippocampus is known to be critical for learning and memory, yet the putative effects of hippocampal dysfunction remain poorly understood in preterm neonates. In particular, while asymmetry of the hippocampus has been well noted both structurally and functionally, how preterm birth impairs hippocampal development and to what extent the hippocampus is asymmetrically impaired by preterm birth have not been well delineated. In this study, we compared volumetric growth and shape development in the hippocampal hemispheres and structural covariance (SC) between hippocampal vertices and cortical thickness in cerebral cortex regions between two groups. We found that premature infants had smaller volumes of the right hippocampi only. Lower thickness was observed in the hippocampal head in both hemispheres for preterm neonates compared with full-term peers, though preterm neonates exhibited an accelerated age-related change of hippocampal thickness in the left hippocampi. The SC between the left hippocampi and the limbic lobe of the premature infants was severely impaired compared with the term-born neonates. These findings suggested that the development of the hippocampus during the third trimester may be altered following early extrauterine exposure with a high degree of asymmetry.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Science and Technology Development Program of Xuzhou

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

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