βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer’s Disease

Author:

Audrain Mickael123,Souchet Benoit134,Alves Sandro13,Fol Romain123,Viode Arthur5,Haddjeri Alexis6,Tada Satoru13,Orefice Nicola S13,Joséphine Charlène37,Bemelmans Alexis-Pierre37,Delzescaux Thierry37,Déglon Nicole89,Hantraye Philippe3710,Akwa Yvette11,Becher François5,Billard Jean-Marie6,Potier Brigitte6,Dutar Patrick6,Cartier Nathalie13,Braudeau Jérôme13ORCID

Affiliation:

1. INSERM UMR1169, Université Paris-Sud, Université Paris-Saclay, Orsay, France

2. Université Paris Descartes, Paris, France

3. CEA, DRF, Institut Francois Jacob, MIRCen, Fontenay-aux-Roses, France

4. Université Paris Saclay, Paris, France

5. CEA, Institut Frédéric Joliot, Service de Pharmacologie et d’Immunoanalyse, Gif-sur-Yvette, France

6. INSERM UMR894, Centre de Psychiatrie et Neurosciences, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

7. CNRS UMR9199, Fontenay-aux-Roses 92265, Université Paris-Sud, Université Paris-Saclay, Orsay, France

8. Department of Clinical Neurosciences, Laboratory of Cellular and Molecular Neurotherapies, Lausanne University Hospital, Lausanne, Switzerland

9. Neuroscience Research Center, Laboratory of Cellular and Molecular Neurotherapies, Lausanne University Hospital, Lausanne, Switzerland

10. INSERM UMS27, Fontenay-aux-Roses 92265, Université Paris-Sud, Université Paris-Saclay, Orsay, France

11. INSERM U1195 and Université Paris Sud and Université Paris-Saclay, 80 rue du général Leclerc, Le Kremlin-Bicêtre, France

Funder

DIM Biotherapies

the Région Ile-de-France

IDEX Paris Saclay

INSERM Transfert

CEA

Investissement d’Avenir

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

Reference35 articles.

1. Laboratory animals: the Renaissance rat;Abbott;Nature,2004

2. Engineering theranostic nanovehicles capable of targeting cerebrovascular amyloid deposits;Agyare;J Control Release,2014

3. Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain;Alves;Sci Rep,2016

4. Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression;Audrain;Mol Neurodegener,2016

5. Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer’s disease;Augustinack;Acta Neuropathol,2002

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