Striatal BOLD and Midfrontal Theta Power Express Motivation for Action

Author:

Algermissen Johannes1ORCID,Swart Jennifer C1,Scheeringa René12,Cools Roshan13,den Ouden Hanneke E M1

Affiliation:

1. Donders Institute for Brain, Cognition and Behaviour, Radboud University, Thomas van Aquinostraat 4, 6525 GD Nijmegen, The Netherlands

2. Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Kokereiallee 7, 45141 Essen, Germany

3. Department of Psychiatry, Radboud University Medical Centre, Reinier Postlaan 10, 6525 GC Nijmegen, The Netherlands

Abstract

Abstract Action selection is biased by the valence of anticipated outcomes. To assess mechanisms by which these motivational biases are expressed and controlled, we measured simultaneous EEG-fMRI during a motivational Go/NoGo learning task (N = 36), leveraging the temporal resolution of EEG and subcortical access of fMRI. VmPFC BOLD encoded cue valence, importantly predicting trial-by-trial valence-driven response speed differences and EEG theta power around cue onset. In contrast, striatal BOLD encoded selection of active Go responses and correlated with theta power around response time. Within trials, theta power ramped in the fashion of an evidence accumulation signal for the value of making a “Go” response, capturing the faster responding to reward cues. Our findings reveal a dual nature of midfrontal theta power, with early components reflecting the vmPFC contribution to motivational biases, and late components reflecting their striatal translation into behavior, in line with influential recent “value of work” theories of striatal processing.

Funder

James S. McDonnell Foundation

Netherlands Organization for International Cooperation in Higher Education

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

Reference98 articles.

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