Synapses from the Motor Cortex and a High-Order Thalamic Nucleus are Spatially Clustered in Proximity to Each Other in the Distal Tuft Dendrites of Mouse Somatosensory Cortex

Author:

Kim Nari1,Bahn Sangkyu2,Choi Joon Ho1,Kim Jinseop S23,Rah Jong-Cheol14ORCID

Affiliation:

1. Laboratory of Neurophysiology, Korea Brain Research Institute, Daegu 41067, Republic of Korea

2. Laboratory of Computational Neuroscience, Korea Brain Research Institute, Daegu 41067, Republic of Korea

3. Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea

4. Department of Brain & Cognitive Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu 42988, Republic of Korea

Abstract

Abstract The posterior medial nucleus of the thalamus (POm) and vibrissal primary motor cortex (vM1) convey essential information to the barrel cortex (S1BF) regarding whisker position and movement. Therefore, understanding the relative spatial relationship of these two inputs is a critical prerequisite for acquiring insights into how S1BF synthesizes information to interpret the location of an object. Using array tomography, we identified the locations of synapses from vM1 and POm on distal tuft dendrites of L5 pyramidal neurons where the two inputs are combined. Synapses from vM1 and POm did not show a significant branchlet preference and impinged on the same set of dendritic branchlets. Within dendritic branches, on the other hand, the two inputs formed robust spatial clusters of their own type. Furthermore, we also observed POm clusters in proximity to vM1 clusters. This work constitutes the first detailed description of the relative distribution of synapses from POm and vM1, which is crucial to elucidate the synaptic integration of whisker-based sensory information.

Funder

National Research Foundation of Korea

DGIST R&D Program

KBRI Research Program

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

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