Concomitant Processing of Choice and Outcome in Frontal Corticostriatal Ensembles Correlates with Performance of Rats

Author:

Handa Takashi123,Harukuni Rie3,Fukai Tomoki34

Affiliation:

1. Department of Behavior and Brain Organization, Center Advanced European Study and Research (Caesar), Bonn 53175, Germany

2. Department of Neurobiology, Graduate School of Biomedical and Health Sciences (Medicine), Hiroshima University, Hiroshima 734-8553, Japan

3. Laboratory for Neural Coding and Brain Computing, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan

4. Neural Coding and Brain Computing Unit, Okinawa Institute of Science and Technology, Okinawa 904-0495, Japan

Abstract

Abstract The frontal cortex-basal ganglia network plays a pivotal role in adaptive goal-directed behaviors. Medial frontal cortex (MFC) encodes information about choices and outcomes into sequential activation of neural population, or neural trajectory. While MFC projects to the dorsal striatum (DS), whether DS also displays temporally coordinated activity remains unknown. We studied this question by simultaneously recording neural ensembles in the MFC and DS of rodents performing an outcome-based alternative choice task. We found that the two regions exhibited highly parallel evolution of neural trajectories, transforming choice information into outcome-related information. When the two trajectories were highly correlated, spike synchrony was task-dependently modulated in some MFC-DS neuron pairs. Our results suggest that neural trajectories concomitantly process decision-relevant information in MFC and DS with increased spike synchrony between these regions.

Funder

KAKENHI

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

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