Identifying interindividual variability of social perception and associated brain anatomical correlations in children with autism spectrum disorder using eye-tracking and diffusion tensor imaging MRI (DTI-MRI)

Author:

Vinçon-Leite Alice12,Saitovitch Ana1,Lemaître Herve3,Rechtman Elza4,Boisgontier Jennifer1,Fillon Ludovic1,Philippe Anne56,Rio Marlène7,Desguerre Isabelle8,Fabre Aurélie1,Aljabali Khawla1,Boddaert Nathalie1,Zilbovicius Monica1

Affiliation:

1. Institut Imagine, UMR 1163, INSERM U1299, Department of Pediatric Radiology, Necker-Enfants Malades Hospital , AP-HP, Université Paris Cité, 75015 Paris , France

2. Department for Autism, SATORI, Henri Guérin Hospital , Pierrefeu du Var 83390 , France

3. Institut des Maladies Neurodégénératives , CNRS UMR 5293, Université de bordeaux, Centre Broca Nouvelle-Aquitaine, Bordeaux , France

4. Department of Environmental Medicine and Public Health, Icahn School of Medecine at Mount Sinai , New York, NY 10029 , United States

5. Developmental Brain Disorders Laboratory , Imagine Institute, , 75015 Paris , France

6. Université Paris Cité , Imagine Institute, , 75015 Paris , France

7. Service de Médecine Génomique des Maladies Rares, Hôpital Necker-Enfants Malades, APHP-Centre, Paris, France. Laboratoire de génétique des troubles du neurodéveloppement, Institut Imagine, Université de Paris , 75015 Paris , France

8. Paediatric Neurology Department, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University , 75015 Paris , France

Abstract

Abstract Even though deficits in social cognition constitute a core characteristic of autism spectrum disorders, a large heterogeneity exists regarding individual social performances and its neural basis remains poorly investigated. Here, we used eye-tracking to objectively measure interindividual variability in social perception and its correlation with white matter microstructure, measured with diffusion tensor imaging MRI, in 25 children with autism spectrum disorder (8.5 ± 3.8 years). Beyond confirming deficits in social perception in participants with autism spectrum disorder compared 24 typically developing controls (10.5 ± 2.9 years), results revealed a large interindividual variability of such behavior among individuals with autism spectrum disorder. Whole-brain analysis showed in both autism spectrum disorder and typically developing groups a positive correlation between number of fixations to the eyes and fractional anisotropy values mainly in right and left superior longitudinal tracts. In children with autism spectrum disorder a correlation was also observed in right and left inferior longitudinal tracts. Importantly, a significant interaction between group and number of fixations to the eyes was observed within the anterior portion of the right inferior longitudinal fasciculus, mainly in the right anterior temporal region. This additional correlation in a supplementary region suggests the existence of a compensatory brain mechanism, which may support enhanced performance in social perception among children with autism spectrum disorder.

Funder

Fondation Orange and Fondation de France

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3