Cognitive Processing Speed Is Strongly Related to Driving Skills, Financial Abilities, and Other Instrumental Activities of Daily Living in Persons With Mild Cognitive Impairment and Mild Dementia-Reference-Cited by-同舟云学术

Cognitive Processing Speed Is Strongly Related to Driving Skills, Financial Abilities, and Other Instrumental Activities of Daily Living in Persons With Mild Cognitive Impairment and Mild Dementia

Published:2020-12-12 Issue:10 Volume:76 Page:1829-1838
ISSN:1079-5006
Container-title:The Journals of Gerontology: Series A
language:en
Short-container-title:

Author:

Wadley Virginia G¹²³,Bull Tyler P²,Zhang Yue¹,Barba Cheyanne²,Bryan R Nick⁴,Crowe Michael²,Desiderio Lisa⁵,Deutsch Georg⁶,Erus Guray⁵,Geldmacher David S⁷⁸^ORCID,Go Rodney⁹,Lassen-Greene Caroline L²¹⁰,Mamaeva Olga A⁹,Marson Daniel C⁸,McLaughlin Marianne¹⁸,Nasrallah Ilya M⁵,Owsley Cynthia³,Passler Jesse²¹¹,Perry Rodney T⁹,Pilonieta Giovanna⁸,Steward Kayla A²¹²,Kennedy Richard E¹^ORCID

Affiliation:

1. Department of Medicine, University of Alabama at Birmingham

2. Department of Psychology, University of Alabama at Birmingham

3. Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham

4. Department of Diagnostic Medicine, Dell Medical School, The University of Texas at Austin

5. Department of Radiology, University of Pennsylvania, Philadelphia

6. Department of Radiology, University of Alabama at Birmingham

7. Department of Neurobiology, University of Alabama at Birmingham

8. Department of Neurology, University of Alabama at Birmingham

9. Department of Epidemiology, University of Alabama at Birmingham

10. Tennessee Valley Veterans Affairs Geriatric Research Education Clinical Center, Nashville

11. Department of Rehabilitation, Psychology and Neuropsychology, Baylor College of Medicine/TIRR Memorial Hermann, Houston, Texas

12. Department of Mental Health and Behavioral Sciences, James A. Haley Veterans’ Hospital, Tampa, Florida

Abstract

Abstract Background Cognitive processing speed is important for performing everyday activities in persons with mild cognitive impairment (MCI). However, its role in daily function has not been examined while simultaneously accounting for contributions of Alzheimer’s disease (AD) risk biomarkers. We examine the relationships of processing speed and genetic and neuroimaging biomarkers to composites of daily function, mobility, and driving. Method We used baseline data from 103 participants on the MCI/mild dementia spectrum from the Applying Programs to Preserve Skills trial. Linear regression models examined relationships of processing speed, structural magnetic resonance imaging (MRI), and genetic risk alleles for AD to composites of performance-based instrumental activities of daily living (IADLs), community mobility, and on-road driving evaluations. Results In multivariable models, processing speed and the brain MRI neurodegeneration biomarker Spatial Pattern of Abnormality for Recognition of Early Alzheimer’s disease (SPARE-AD) were significantly associated with functional and mobility composite performance. Better processing speed and younger age were associated with on-road driving ratings. Genetic risk markers, left hippocampal atrophy, and white matter lesion volumes were not significant correlates of these abilities. Processing speed had a strong positive association with IADL function (p < .001), mobility (p < .001), and driving (p = .002). Conclusions Cognitive processing speed is strongly and consistently associated with critical daily functions in persons with MCI in models including genetic and neuroimaging biomarkers of AD risk. SPARE-AD scores also significantly correlate with IADL performance and mobility. Results highlight the central role of processing speed in everyday task performance among persons with MCI/mild dementia.

Funder

National Institute on Aging

Publisher

Oxford University Press (OUP)

Subject

Geriatrics and Gerontology,Aging

Link

http://academic.oup.com/biomedgerontology/advance-article-pdf/doi/10.1093/gerona/glaa312/35928776/glaa312.pdf

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