Affiliation:
1. The Irish Longitudinal Study on Ageing (TILDA), School of Medicine, Trinity College Dublin , Dublin , Ireland
2. Discipline of Medical Gerontology, School of Medicine, Trinity College Dublin , Dublin , Ireland
3. Teagasc, Food Research Centre , Ashtown, Dublin , Ireland
Abstract
Abstract
Background
Sarcopenia and orthostatic hypotension are growing age-related health burdens associated with adverse outcomes, including falls. Despite a possible pathophysiological link, the association between the 2 disorders is not well elucidated. We sought to investigate this relationship in The Irish Longitudinal Study on Ageing (TILDA).
Methods
Data from 2 858 participants at wave 3 of TILDA were analyzed. Probable sarcopenia was defined as per the European Working Group on Sarcopenia in Older People revised definition cutoffs (hand grip strength [HGS] <27 kg in men, <16 kg in women, and/or 5-chair stand test [5CST] time >15 seconds). Participants underwent an active stand orthostatic test with continuous blood pressure (BP) monitoring. Multilevel mixed-effects models, controlling for possible confounders, were used to assess the effect of probable sarcopenia by HGS and 5CST criteria on the change in BP after standing.
Results
HGS- and 5CST-defined probable sarcopenia were independently associated with an attenuated BP recovery at 10–20 seconds poststand (systolic BP: β −0.54, p < .001; β −0.25, p < .001). On average, those meeting HGS probable sarcopenia criteria had a significantly lower BP at 20, 30, and 40 seconds (differences in systolic BP: −5.01 mmHg, −3.68 mmHg, −2.32 mmHg, p < .05 for all). Those meeting 5CST probable sarcopenia criteria had a significant difference in systolic BP at 20 seconds (−1.94 mmHg, p = .002) but not at 30 or 40 seconds.
Conclusion
Probable sarcopenia had a significant association with delayed orthostatic BP recovery, with HGS-defined probable sarcopenia having a stronger association than 5CST-defined probable sarcopenia. Results support a modest but significant pathophysiological link between probable sarcopenia and orthostatic hypotension.
Funder
Science Foundation Ireland
Atlantic Philanthropies
Irish Department of Health and Irish Life
Publisher
Oxford University Press (OUP)
Subject
Geriatrics and Gerontology,Aging
Cited by
2 articles.
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