1. Bioinformatics and Computational Biology Program, Iowa State University, Ames, IA 50011, USA
2. Center for Metabolic Biology, Iowa State University, Ames, IA 50011, USA
3. Department of Genetics Development and Cell Biology, Iowa State University, Ames, IA 50011, USA
4. Department of Statistics, Iowa State University, Ames, IA 50011, USA