1. Department of Biomedical Sciences, College of Veterinary Medicine, 2Department of Molecular Biology and Genetics, 3Department of Biomedical Engineering, 4Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA, 5Department of Biomedical Engineering, Dongguk University, Seoul, South Korea and 6Department of Biological Sciences and Institute for RNA Science and Technology, University at Albany, State University of New York, Albany, NY 12222, USA