Affiliation:
1. Brain Metastasis Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
Abstract
Abstract
Modeling of metastatic disease in animal models is a critical resource to study the complexity of this multi-step process in a relevant system. Available models of metastatic disease to the brain are still far from ideal but they allow to address specific aspects of the biology or mimic clinically relevant scenarios. We not only review experimental models and their potential improvements but also discuss specific answers that could be obtained from them on unsolved aspects of clinical management.
Funder
Ministerio de Ciencia e Innovación
Fundació La Marató de TV3
Fundación Ramón Areces
Worldwide Cancer Research
Cancer Research Institute
Publisher
Oxford University Press (OUP)
Subject
Electrical and Electronic Engineering,Building and Construction
Cited by
12 articles.
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