Decoding vesicle-based precision oncology in gliomas

Author:

Batool Syeda Maheen1,Hsia Tiffaney1,Khanna Sirena K1,Gamblin Austin S1,Rosenfeld Yulia1,You Dong Gil1,Carter Bob S12,Balaj Leonora12

Affiliation:

1. Department of Neurosurgery, Massachusetts General Hospital , Boston, Massachusetts , USA

2. Department of Neurosurgery, Harvard Medical School , Boston, Massachusetts , USA

Abstract

Abstract Extracellular vesicles (EVs) represent a valuable tool in liquid biopsy with tremendous clinical potential in diagnosis, prognosis, and therapeutic monitoring of gliomas. Compared to tissue biopsy, EV-based liquid biopsy is a low-cost, minimally invasive method that can provide information on tumor dynamics before, during, and after treatment. Tumor-derived EVs circulating in biofluids carry a complex cargo of molecular biomarkers, including DNA, RNA, and proteins, which can be indicative of tumor growth and progression. Here, we briefly review current commercial and noncommercial methods for the isolation, quantification, and biochemical characterization of plasma EVs from patients with glioma, touching on whole EV analysis, mutation detection techniques, and genomic and proteomic profiling. We review notable advantages and disadvantages of plasma EV isolation and analytical methods, and we conclude with a discussion on clinical translational opportunities and key challenges associated with the future implementation of EV-based liquid biopsy for glioma treatment.

Publisher

Oxford University Press (OUP)

Subject

Electrical and Electronic Engineering,Building and Construction

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